Design, synthesis, and biological evaluation of novel thiourea derivatives as small molecule inhibitors for prostate specific membrane antigen.

Prostate cancer (PCa) has emerged to be the second leading cause of cancer-related deaths in men. Molecular imaging of PCa using targeted radiopharmaceuticals specifically to PCa cells promises accurate staging of primary disease, detection of localized and metastasized tumours, and helps predict the progression of the disease. Glutamate urea heterodimers have been popularly used as high-affinity small molecules in the binding pockets of popular and well-characterized PCa biomarker, prostate specific membrane antigen (PSMA).

Acute compartment syndrome leading to fasciotomy, severe morbidity and long-term disabilities following Sri Lankan Green pit viper (Peltopelor trigonocephalus) envenomation.

Green pit viper (Peltopelor trigonocephalus) is a medically important endemic snake in Sri Lanka. Its envenoming commonly causes local effects such as pain, swelling, blistering, and lymphadenopathy and rarely causes venom-induced consumption coagulopathy as a systemic effect. Despite its frequent encounters in estates, commonly tea and cinnamon plantations, reports of envenoming are rare and limited to nine reports in the literature.

Unilateral pulmonary agenesis with ipsilateral facial congenital anomalies in an adult with obstructive airway disease.

Pulmonary agenesis is a rare congenital anomaly which can be isolated or co-exist with other developmental defects. Boyden et al has described three degrees of mal development of lung which include agenesis, hypoplasia and aplasia. Almost all the reported cases are in paediatric age group patients while, adults with pulmonary developmental abnormalities are sparsely documented in the literature.