A Novel Formulation Strategy to Deliver Combined DNA and VLP Based HPV Vaccine.

Human papillomaviruses (HPV) are small, double-stranded DNA viruses that cause cervical cancer, the second most lethal cancer among women in the world. Currently, two vaccines are on the market for preventing HPV-caused cervical cancers and warts. Both are virus-like particle (VLP)-based vaccines.

Overview and Future Potential of Fast Dissolving Buccal Films as Drug Delivery System for Vaccines.

Vaccination is considered one of the most successful public health interventions of the modern era. Vaccines are categorized based on the antigen used, delivery system and the route of administration. Traditional vaccines are produced from the dead, attenuated or inactivated pathogens that cause disease.

Melatonin use in an inpatient academic medical center: Factors affecting provider documentation of patients' sleep quality.

Objectives: Melatonin is commonly prescribed for insomnia despite the 2017 American Academy of Sleep Medicine recommendation against its use due to lack of evidence for efficacy and information on adverse effects. The objectives of this study were to determine what percentage of prescribers document the impact of melatonin on sleep quality in hospitalized patients and to examine factors influencing provider documentation.

Methods: In this single-center retrospective study, electronic medical records of 200 adults with orders for melatonin over a 6-month period were reviewed.

Oral ivermectin for the treatment of head lice infestation.

Purpose: Published literature describing the use of oral ivermectin for the treatment of head lice infestation is reviewed.

Summary: In the United States and globally, head lice infestation, or pediculosis capitis, remains a public health issue with both social and medical implications. Treatment with oral or topical medications is typically required for head lice eradication.

Aerobic Exercise Training as a Potential Cardioprotective Strategy to Attenuate Doxorubicin-Induced Cardiotoxicity.

Doxorubicin is one of the most commonly used cytotoxic anticancer drugs against several cancers.  Although a highly effective anticancer drug, the clinical use of doxorubicin is severely limited by its cardiotoxicity which results in morbidity, poor quality of life, and premature mortality.  Only very few clinically accepted methods to minimize doxorubicin-induced cardiac injury are available today, but none of them have proven to be completely successful.