Design, Synthesis, and Application of an Optimized Monofluorinated Aliphatic Label for Peptide Studies by Solid-State F NMR Spectroscopy.

A conformationally restricted monofluorinated α-amino acid, (3-fluorobicyclo[1.1.1]pentyl)glycine (F-Bpg), was designed as a label for the structural analysis of membrane-bound peptides by solid-state F NMR spectroscopy.

1-Alkyl-5-((di)alkylamino) tetrazoles: building blocks for peptide surrogates.

An approach to the synthesis of 1-alkyl-5-((di)alkylamino)tetrazoles by nucleophilic substitution in 1-alkyl-5-sulfonyltetrazoles with anions generated from the primary or secondary amines was developed. Tolerance of the method to the presence of some functional groups (i.e.

Stochastic effects at ripple formation processes in anisotropic systems with multiplicative noise.

We study pattern formation processes in anisotropic system governed by the Kuramoto-Sivashinsky equation with multiplicative noise as a generalization of the Bradley-Harper model for ripple formation induced by ion bombardment. For both linear and nonlinear systems we study noise-induced effects at ripple formation and discuss scaling behavior of the surface growth and roughness characteristics. It was found that the secondary parameters of the ion beam (beam profile and variations of an incidence angle) can crucially change the topology of patterns and the corresponding dynamics.

[Current approaches to the diagnosis and treatment of pilots with combined polyposis of the stomach and large intestine].

Findings of diagnostics and treatment of 198 pilots suffering from combined polyposis in the stomach and large intestine are presented. Different therapeutic tactics should be chosen for these patients. Annual dynamic evaluation should be made in case of a benign course and without an upward tendency, whereas diagnosed villus polyps, villus-tubular adenoma with the second or third phase of dysplasia, adenomatous polyps with regional 2nd or 3d phase dysplasia will require early polypectomy to be followed by yearly dynamic endoscopy.