Publications by authors named "S A Klumpp"
Article Synopsis
- The synaptic vesicle cluster (SVC) is critical for releasing neurotransmitters at chemical synapses and also helps regulate various cofactors involved in exo- and endocytosis.
- It contains various molecules important for synaptic processes, including cytoskeletal elements and adhesion proteins, and influences the positioning and activity of key organelles like mitochondria.
- Changes in the size of the SVC may align with alterations in the postsynaptic area, indicating that it plays a central role in synchronizing pre- and postsynaptic functions, which warrants further research into its regulatory mechanisms.
Filamentous cyanobacteria are one of the oldest and today still most abundant lifeforms on earth, with manifold implications in ecology and economics. Their flexible filaments, often several hundred cells long, exhibit gliding motility in contact with solid surfaces. The underlying force generating mechanism is not yet understood.
View Article and Find Full Text PDFPhenotype switching can be triggered by external stimuli and by intrinsic stochasticity. Here, we focus on the motility-matrix production switch in . We use modeling to describe the SinR-SlrR bistable switch and its regulation by SinI and to distinguish different sources of stochasticity.
View Article and Find Full Text PDFCell mechanics are determined by an intracellular biopolymer network, including intermediate filaments that are expressed in a cell-type-specific manner. A prominent pair of intermediate filaments are keratin and vimentin, as they are expressed by non-motile and motile cells, respectively. Therefore, the differential expression of these proteins coincides with a change in cellular mechanics and dynamic properties of the cells.
View Article and Find Full Text PDFArticle Synopsis
- PETRA III at DESY is a top-notch synchrotron radiation source, delivering powerful X-rays for a variety of scientific experiments across many fields.
- It currently operates 25 specialized beamlines and has a storage-ring energy of 6 GeV.
- The planned PETRA IV upgrade will increase brightness significantly, making it an advanced tool for studying biological, chemical, and physical processes, addressing major global challenges.