Indirectly acquired fear memories have distinct, sex-specific molecular signatures from directly acquired fear memories.

Post-traumatic stress disorder (PTSD) is a severe anxiety disorder that affects women more than men. About 30% of patients suffering from PTSD develop the disorder by witnessing a traumatic event happen to someone else. However, as the focus has remained on those directly experiencing the traumatic event, whether indirectly acquired fear memories that underlie PTSD have the same molecular signature as those that are directly acquired remains unknown.

Dysregulation of baseline and learning-dependent protein degradation in the aged hippocampus.

The ubiquitin-proteasome system (UPS) controls the majority of protein degradation in cells and dysregulation of the UPS has been implicated in the pathophysiology of numerous neurodegenerative disorders, including Alzheimer's disease. Further, strong evidence supports a critical role for the UPS in synaptic plasticity and memory formation. However, while proteasome function is known to decrease broadly in the brain across the lifespan, whether it changes in the hippocampus, a region critical for memory storage and among the first impacted in Alzheimer's disease, at rest and following learning in the aged brain remains unknown.

Monoubiquitination of histone H2B is a crucial regulator of the transcriptome during memory formation.

Posttranslational modification of histone proteins is critical for memory formation. Recently, we showed that monoubiquitination of histone H2B at lysine 120 (H2Bub) is critical for memory formation in the hippocampus. However, the transcriptome controlled by H2Bub remains unknown.

Gradual Change Procedures in Behavior Analysis.

A wide variety of procedures within behavior analysis use gradual change in stimuli, response requirements, reinforcement, or some combination thereof, to effectively change behavior. Such procedures include shaping, thinning, fading, and chaining. Collectively, gradual change procedures represent a conceptually systematic technology of behavior change with wide-ranging empirical support across diverse settings and contexts.

Venous thromboembolism (VTE) risk stratification in general medical patients at an academic medical center.

Hospital-acquired venous thromboembolism (VTE) is still a concern for general medical patients. Pharmacologic prophylaxis can reduce VTE incidence, but there is the potential for adverse effects. Therefore, determining which patients should receive VTE prophylaxis via risk scoring tools is essential.