Publications by authors named "S A Khurram"
Herein, we reported mutations in five DNA Damage Repair (DDR) i.e., TP53, ATR, ATM, CHEK1 and CHEK2 involved in OSCC using NG-WES and their analysis using bioinformatics tools.
View Article and Find Full Text PDFAims: Oral epithelial dysplasia (OED) carries a risk of malignant transformation to oral squamous cell carcinoma. Clinical risk stratification for these patients is challenging, and reliant upon histological grading. The World Health Organisation (WHO) grading system is the current gold standard, although the binary system, two- and six-point prognostic models have also been proposed.
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- Oral epithelial dysplasia (OED) is challenging due to its risk of turning malignant and the unreliability of current grading systems to predict this, leading to high observer variability.
- A new AI-based score focusing on intra-epithelial lymphocytes (IELs) was developed to assess OED using a digital dataset of 219 tissue samples, which outperformed traditional pathologist evaluations.
- The study found that higher IEL scores were significantly linked to more severe OED and a greater likelihood of malignant transformation, suggesting IELs could serve as valuable prognostic indicators.
Article Synopsis
- The study investigates the connection between the olfactory system and COVID-19 symptoms like loss of smell (anosmia) and taste (hypogeusia) by examining the role of the nervus terminalis (NT) using ultra-high-field 7T MRI imaging.
- Researchers evaluated brain images from 45 COVID-19 patients and 29 healthy controls to identify the presence of NT, olfactory bulbs (OB), and signs of brain volume loss or changes in signal intensity.
- The results showed that NT was visible in all participants, with COVID-19 patients experiencing anosmia or hypogeusia showing significant T2 hyperintensity in NT, OB, and olfactory tract (OT) compared to controls and
Article Synopsis
- The study investigates the genetic diversity and population structure of the common walnut tree across 46 populations in Central Asia, involving 1082 individual specimens.
- Results showed moderate genetic diversity and identified the western Himalaya as a key region for genetic variation, with some populations likely introduced by humans.
- The research suggests that historical climate changes and human activities have influenced walnut genetics, and highlights the need for conservation efforts to protect this genetic diversity, especially in the western Himalaya and Gongliu region.