[Glymphatic dysfunction and sleep disorders: indirect effects on Alzheimer's disease].

Modern research raises the question of the potentially significant role of glymphatic dysfunction in the development of neurodegeneration and pathological aging. The exact molecular mechanisms are not yet fully understood, but there is ample evidence of a link between sleep deprivation and decreased clearance of β-amyloid and other neurotoxin proteins that are associated with the development of neurodegenerative diseases, particularly Alzheimer's disease. The review analyzes current scientific information in this area of research, describes the latest scientific discoveries of the features of the glymphatic system, and also illustrates studies of markers that presumably indicate a deterioration in the glymphatic system.

EFFECT OF IMUNOFAN INFLUENCE ON THE STRUCTURE OF THE TESTES, HORMONAL AND CYTOKINE PROFILE OF IMMATURE EXPERIMENTAL ANIMALS.

Objective: The aim: It was the establishing the features of changes in the structure of the testes of experimental animals, as well as immunological, hormonal and cytokine parameters of blood plasma during stimulation.

Patients And Methods: Materials and methods: The study was carried out on 60 white male immature rats. Imunofan was used at a dosage of 50 υg.

Dynamics of advectively coupled Van der Pol equations chain.

A ring chain of the coupled Van der Pol equations with two types of unidirectional advective couplings is considered. It is assumed that the number of elements in the chain is sufficiently large. The transition to a distributed model with a continuous spatial variable is realized.