[State of homeostasis under administration of bear fat in rats with exogenous and endogenous thrombinemia].

In experimental studies on 448 rats treated with bear fat diet (0.08 ml/100 g body weight), the nature and mechanisms of influence of this additive on the process of blood coagulation in experimental thromboplastinemia of different origin has been studied. As a result of intravenous injection in the jugular vein of a suspension of thrombin (exog­enous thrombinemia) all clothingsee tests lengthened in the control animals (p<0.

Morphofunctional changes in the kidneys in chronic endotoxemia against the background of hypothyroidism.

We studied morphological structure of the kidneys in chronic endotoxemia modeled against the background of hypothyroidism. The detected changes did not differ from those under conditions of basic endotoxemia model and were characterized by the development of glomerulosclerosis and glomerulohyalinosis. The changes were less severe in rats with hypothyroidism and appeared at the late terms of the experiment.

Morphofunctional characteristics of the kidneys in chronic endotoxemia against the background of hyperthyroidism.

Simulation of chronic endotoxemia in rats leads to the development of nephropathy and nephrosclerosis. Kidney involvement was more pronounced in animals with endotoxemia developing against the background of hyperthyroidism. Direct effects of bacterial LPS and its secondary effects mediated through circulating LPO products under conditions of thyroid hormone excess caused damage to the renal tissue.

Morphology of endocrine organs in chronic endogenous intoxication.

Experimental study of the effects of endogenous toxic compounds on endocrine organs showed that the pathomorphological changes were caused by the cytopathic effects of endogenous toxic compounds involving the development of stereotypical reactions to injury. The severity of these reactions depended on the initial functional status of the gland and its involvement in systemic mechanisms of adaptation to the toxic process.

Sex hormone profile and morphological changes in the ovaries in chronic endotoxicosis.

Morphological changes in the ovaries and levels of sex hormones were studied in rats with chronic endotoxicosis. Long-term endogenous intoxication was associated with the development of sclerocystic ovary syndrome paralleled by hormone imbalance.