A Perspective of Multi-Reflecting TOF MS.

Time-of-flight mass spectrometry (TOF MS) excels in rapid and high-sensitivity analysis, making it a cornerstone of analytical chemistry. But as sample complexity explodes in omics studies, so does the need for higher resolving power to ensure accurate results. Traditional TOF instruments face a challenge: achieving high resolution often requires a very large instrument.

Multireflecting gas chromatography-multireflecting time-of-flight mass spectrometer with high dynamic range.

Gas chromatography-mass spectrometry (GC-MS) is a cornerstone technique for analyses of volatile and semivolatile compounds, constantly evolving to meet new challenges. The adoption of time-of-flight mass spectrometers (TOFMS) has enhanced GC-MS with faster spectral acquisition and broader mass coverage, enabling rapid GC separations. Multireflecting TOFMS (MRT) further improves resolution compared to traditional single-reflecting TOFMS, facilitating the detection of minor analytes within complex matrices.

Collective dynamics and shot-noise-induced switching in a two-population neural network.

Neural mass models are a powerful tool for modeling of neural populations. Such models are often used as building blocks for the simulation of large-scale neural networks and the whole brain. Here, we carry out systematic bifurcation analysis of a neural mass model for the basic motif of various neural circuits, a system of two populations, an excitatory, and an inhibitory ones.

Modeling Known Sources of Mass Calibration Deviations in High Resolution ToF MS.

Modern time-of-flight mass spectrometer instruments exhibit excellent mass accuracy in the parts per billion range. At this level, mass calibration methods should consider potential distortions in the basic calibration. Factors which can cause distortions are to be under control.