Publications by authors named "S A Jeddi"
One possible reason for failure in achieving optimal glycemic control in patients with type 2 diabetes (T2D) is that less attention has been paid to the brain, a fundamental player in glucose homeostasis, that consumes about 25% of total glucose utilization. In addition, animal and human studies indicate that nitric oxide (NO) is a critical player in glucose metabolism. NO synthesis from L-arginine is lower in patients with T2D, and endothelial NO synthase (eNOS)-derived NO bioavailability is lower in T2D.
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- Type 2 diabetes (T2D) increases the risk of vascular complications, which lead to over 50% of deaths in T2D patients, due to impairments in both endothelial and vascular smooth muscle cells.
- A systematic review analyzed 44 clinical trial studies and found significant reductions in both endothelial-dependent and independent vascular smooth muscle (VSM) relaxation in T2D patients compared to controls.
- The study highlighted that the decrease in relaxation responses was more significant for methacholine (55%) and glyceryl trinitrate (63%) than for acetylcholine (30%) and sodium nitroprusside (17%).*
Chronic Inorganic Nitrate Administration Increases the Expression of Genes Involved in the Browning of Gonadal Adipose Tissue in Ovariectomized Rats.
Endocr Metab Immune Disord Drug Targets
June 2024
Background And Objective: Nitrate, as nitric oxide (NO) donor, has been suggested as a nutrition-based treatment for decreasing the risk of menopause-related obesity. This study aimed to specify the effects of chronic inorganic nitrate administration on uncoupling protein-1 (UCP-1), peroxisome proliferator-activated-receptor-947; (PPAR-947;) coactivator-1945; (PGC-1945;), and PPAR-947; expression in gonadal adipose tissue (GAT) of ovariectomized (OVX) rats.
Methods: Female rats were assigned to 3 groups: Control, OVX, and OVX+nitrate (n=7/group), which consumed water containing inorganic nitrate (100 mg/L) for 9 months.
Background: Childhood exercise enhances brain structure, while diabetes detrimentally affects it. This study examines early-life exercise's influence on adult diabetic rats' memory and neuroplasticity.
Methods: Male Wistar pups were divided into Control, Diabetes, Exercise Training, and Diabetes exercise groups.
Menopause is associated with reduced nitric oxide (NO) bioavailability and lower tolerance against myocardial ischemia-reperfusion (IR) injury. This study investigated whether long-term nitrate administration provides resistance against myocardial IR injury in ovariectomized (OVX) rats. After ovariectomy, female rats were assigned to the OVX and the OVX + nitrate groups ( = 14/group); the latter group consumed nitrate (100 mg/L) for 9 months.
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