Cervical cancer poses a significant challenge to global health, particularly in low- and middle-income countries. Tracking the survival rates of cancer patients through data gathered by population-based cancer registries constitutes a crucial aspect of cancer management. In recent years, attention within bibliometric studies has been directed towards examining the correlation between inflammation and radiotherapy in cervical cancer.
View Article and Find Full Text PDFThe impact of clinical stage on the effectiveness of osimertinib for epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC) remains unexamined. We investigated osimertinib therapeutic efficacy variation between stage IVA or lower and stage IVB EGFR mutation-positive lung cancers, focusing on differences in pretreatment co-occurring genetic alterations in circulating tumor DNA. This was a secondary analysis of the ELUCIDATOR study, a multicenter prospective observational study in Japan that assessed the mechanisms underlying resistance to osimertinib as a first-line treatment for advanced NSCLC with EGFR mutations.
View Article and Find Full Text PDFGlobally, nearly 9 million people are living with type 1 diabetes (T1D). Although the incidence of T1D is not affected by socioeconomic status, the development of complications and limited access to modern therapy is overrepresented in vulnerable populations. Diabetes technology, specifically continuous glucose monitoring and automated insulin delivery systems, are considered the gold standard for management of T1D, yet access to these technologies varies widely across countries and regions, and varies widely even within high-income countries.
View Article and Find Full Text PDFThe purpose of this work is to probe the analytical formulation of the mechanical response [Formula: see text], which is the consequence of determining the connection between charge and depth values. It is possible to acquire the [Formula: see text] expression by doing an indentation experiment while the loading process is unfolding. In this particular piece of research, the formulation of [Formula: see text] takes into consideration the pile-up mode for an indenter with a spherical structure.
View Article and Find Full Text PDFBackground: Malaria and human immunodeficiency virus (HIV) infection coexist in significant numbers in some geographic areas including sub-Sahara Africa (SSA). HIV-infected patients are a World Health Organization (WHO) recognized high risk group for increased malaria morbidity. Majority of HIV-infected patients undertaking treatment in SSA are on WHO recognized first-line combination antiretroviral therapy (cART).
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