Publications by authors named "S A Hyland"
Sensing of peptidoglycan fragments is essential for inducing downstream signaling in both mammalian and fungal systems. The hexokinases NagK and Hxk1 are crucial enzymes for the phosphorylation of peptidoglycan molecules in order to activate specific cellular responses; however, biochemical characterization of their enzymatic specificity and efficiency has yet to be investigated in depth. Here a mass spectrometry enzymatic screen was implemented to assess substrate specificity, and an ATP coupled assay provided the quantitative kinetic profiles of these two homologous, eukaryotic enzymes.
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- * PGLYRP-1 is essential for innate immune response in macrophages when triggered by a specific PGN disaccharide (GMTriP-K), but not by other similar compounds, indicating a unique signaling pathway.
- * The study found that PGLYRP-1 interacts with other proteins in cells, localizes to specific cellular structures, and is involved in regulating gene expression linked to intestinal inflammation in both mice and humans.
Disclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
View Article and Find Full Text PDFDisclaimer: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.
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- The Lisfranc complex refers to the connection between the medial cuneiform and the second metatarsal base, commonly injured in high-impact activities.
- A study reviewed the outcomes of 99 patients who received surgical fixation for Lisfranc injuries, divided into those treated within 24 hours and those treated later.
- The results indicated that early surgical treatment did not lead to better outcomes compared to delayed fixation, although there was a slight increase in superficial infections in the early treatment group.