ENHANCED RESTORATION OF VISUAL CODE AFTER TARGETING ON BIPOLAR CELLS COMPARED TO RETINAL GANGLION CELLS WITH OPTOGENETIC THERAPY.

Optogenetic therapy is a promising vision restoration method where light sensitive opsins are introduced to the surviving inner retina following photoreceptor degeneration. The cell type targeted for opsin expression will likely influence the quality of restored vision. However, a like-for-like pre-clinical comparison of visual responses evoked following equivalent opsin expression in the two major targets, ON bipolar (ON BCs) or retinal ganglion cells (RGCs), is absent.

A novel multilayer antimicrobial urinary catheter material with antimicrobial properties.

Urinary catheters are commonly used in medical practice to drain and monitor urine of patients. However, urinary catheterisation is associated with the risk of developing catheter-associated urinary tract infections (CAUTIs), which can result in life-threatening sepsis that requires antibiotics for treatment. Using the layer-by-layer (LbL) technique, we assembled a multilayer catheter comprising nine quadruple layers (9QL) of alginate, chlorhexidine (CHX), alginate and poly(β-amino ester) (PBAE) built upon an amino-functionalised silicone.

Outcomes after index cholecystectomy: a UK longitudinal multi-centre cohort Study.

Purpose: International guidelines for management of acute biliary pathology recommend emergency cholecystectomy (EmC), citing improved outcomes compared to elective cholecystectomy (ElC) based on trials which may not reflect the capacity constraints in clinical practice, nor selection based on multiple prior attendances with emergency biliary pathology or attendances following a decision for ElC. We therefore conducted a longitudinal retrospective study evaluating all attendances with biliary pathology prior to cholecystectomy with the aim of assessing whether EmC is justified in this context.

Methods: Data was collected on patients undergoing cholecystectomy between 2016 and 2021 at four centres.

The role of awareness and demand in evaluative learning.

Human likes and dislikes can be established or changed in numerous ways. Three of the most well-studied procedures involve exposing people to regularities in the environment (evaluative conditioning, approach-avoidance, mere exposure), to verbal information about upcoming regularities (evaluative conditioning, approach-avoidance, or mere exposure information), or to verbal information about the evaluative properties of an attitude object (persuasive messages). In the present study, we investigated the relation between, on the one hand, different types of experiment-related beliefs (regularity, influence, and hypothesis awareness) and demand reactions (demand compliance and reactance) and, on the other hand, evaluative learning about novel food brands (Experiments 1 and 2) and well-known food brands (Experiment 2) via persuasive messages, experienced regularities, and verbal information about regularities.