Publications by authors named "S A Hashem"
Background: A multi-center study in Los Angeles (USC), Kansas City (KUMC) and Dallas (UT-SWMC) quantified via predictive modeling the dynamics of cerebral perfusion regulation (CO2 vasoreactivity and cerebral autoregulation) in MCI/AD patients and cognitively normal controls under resting conditions. The goal was to develop model-based physio-markers for accurate diagnosis of MCI and pre-clinical AD, motivated by our previous findings of significant impairment of cerebral perfusion regulation in MCI and mild AD patients.
Method: Continuous spontaneous changes in arterial blood pressure, end-tidal CO2, cerebral blood flow velocity in middle cerebral arteries and cortical tissue oxygenation at lateral prefrontal cortex were recorded over two 6-8 min sessions, separated by session of slow-paced breathing (6 breaths/minute), in 53 MCI (28 APOE4 non-carriers and 25 APOE4 carriers), 33 mild AD patients (13 APOE4 non-carriers and 20 APOE4 carriers) and 74 age/sex-matched cognitively normal controls (50 APOE4 non-carriers and 24 APOE4 carriers).
Background: Control of breathing is known to be adversely affected by cognitive impairment, often associated with sleep apnea or disordered breathing during sleep in MCI/AD. The origin of this disorder is thought to be in the dysfunction of the respiratory control centers of the brainstem or in the impaired afferent signaling from cortical regions. Continuous breathing data were collected in a multi-center study in Los Angeles (USC), Kansas City (KUMC) and Dallas (UT-SWMC), and used to compute respiratory rate variability (RRV) to test the hypothesis that voluntary control of breathing is impaired in MCI and mild AD patients relative to cognitively normal controls, and whether this impairment is more severe in mild AD than MCI patients.
View Article and Find Full Text PDFPurpose: Inherited retinal disorders (IRD) are a complex group of conditions. By developing the first patient-reported experience measurement (PREM) questionnaire tailored for individuals with IRD participating in natural history studies, we gathered information on individuals' views of their experience while they are involved in research.
Methods: Adults with IRD who (i) were enrolled in a natural history study taking place at Moorfields Eye Hospital (London, UK), (ii) had attended at least two study visits, (iii) the most recent one being less than two weeks before the questionnaire, and (iv) who were not involved in interventional research, were considered for participation.
Article Synopsis
- Oral lichen planus (OLP) is a potentially serious condition of the mouth, and this study explores the potential of platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) as alternatives to corticosteroids for treatment.
- A systematic review of existing randomized controlled trials was conducted, analyzing data from 8 studies involving 157 patients to compare PRP and PRF against corticosteroids based on changes in lesion size, pain, and clinical scores.
- The findings indicate no significant differences between PRF, PRP, and corticosteroids in most outcomes, but PRF consistently ranked highest in reducing lesion sizes and pain scores at various weeks, suggesting it could be a more effective treatment alternative in managing OLP.
Sarcoidosis is a multifaceted systemic disease of uncertain aetiology, pathologically characterised by non-caseating granulomas. Typical symptoms include coughing, dyspnoea, chest pain and lesions affecting the eyes or skin. Cutaneous sarcoidosis frequently accompanies the involvement of other organs, but isolated cutaneous presentations are also observed.
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