Publications by authors named "S A Hakam"
Article Synopsis
- Female X-linked diseases are rare due to X chromosome inactivation, but Rett syndrome (RTT) is an exception caused by MECP2 mutations.
- In a study using mutant mice, researchers found sex differences in gene expression, with mutant females showing significantly more altered genes than males, even before symptoms appeared.
- The study highlights the importance of both cell type and interactions between different cell types in understanding RTT progression, suggesting potential avenues for treatment.
Sodium-glucose co-transporter inhibitors (SGLTis) are the latest class of anti-hyperglycemic agents. In addition to inhibiting the absorption of glucose by the kidney causing glycosuria, these drugs also demonstrate cardio-renal benefits in diabetic subjects. miR-30 family, one of the most abundant microRNAs in the heart, has recently been linked to a setting of cardiovascular diseases and has been proposed as novel biomarkers in kidney dysfunctions as well; their expression is consistently dysregulated in a variety of cardio-renal dysfunctions.
View Article and Find Full Text PDFBackground: Autism spectrum disorder comprises a group of neurodevelopmental conditions currently diagnosed by behavioral assessment in childhood, although neuropathology begins during gestation. A poorly understood male bias for ASD diagnosis is thought to be due to both biological sex differences and cultural biases against female diagnosis of ASD. Identification of molecular biomarkers of ASD likelihood in newborns would provide more objective screening and early intervention.
View Article and Find Full Text PDFArticle Synopsis
- Dominant X-linked diseases, like Rett syndrome (RTT), are rare because females have X chromosome inactivation, which usually protects against such mutations.
- RTT is a neurodevelopmental disorder that appears in girls after a period of normal development, leading to a regression of skills that researchers still don't fully understand.
- A study using single-nucleus RNA sequencing on a mouse model of RTT found significant sex differences in gene expression, revealing that mutant females had more affected genes than males, which could be vital for understanding disease progression and potential treatments.
Article Synopsis
- Lithium-sulfur batteries are seen as a promising future energy source, but face challenges like low cycling stability and effective use of sulfur.
- A new approach using a modified metal-organic framework creates a specialized porous carbon material that helps capture and convert lithium polysulfides more efficiently.
- Testing showed exceptional results with high capacity and stability over time, demonstrating strong performance in terms of power density and energy, supported by theoretical insights into the material interactions.