Experimental Use of Common Marmosets (Callithrix jacchus) in Preclinical Trials of Antiviral Vaccines.

Common marmoset (, CM) is a New World primate species that is of interest for preclinical trials of immunobiological products. In this study, we describe the approaches to long-term laboratory breeding and maintenance of CMs. We also establish the reference values of the main complete blood count and serum chemistry parameters evaluated during preclinical trials of immunobiological products and describe the histological characteristics of CM lymphoid organs during the development of post-vaccination immune response.

Accelerated Method for Determining Ischemic Brain Damage in Rats and Assessment the Neuroprotective Effect of a Complex Herbal Remedy.

The severity of ischemic injury was evaluated by densitometry of brain samples stained with 2,3,5-triphenyltetrazolium chloride (TTC) on a rat model of cerebral ischemia/reperfusion (common carotid artery occlusion) and the neuroprotective activity of an extract of Astragalus membranaceus, Scutellaria baicalensis, and Phlojodicarpus sibiricus was assessed. Occlusion of the common carotid arteries led to a weakening of TTC staining of the brain tissue: densitometric indicators of the staining intensity for the cortex and striatum were lower than the corresponding indicators of sham-operated rats by 18.3 and 10.

EEG Microstate Analysis and the EEG Inverse Problem Solution as a Tool for Diagnosing Cognitive Dysfunctions in Individuals Who Have Had a Mild Form of COVID-19.

The term "postcovid syndrome" is firmly entrenched in medical terminology, however, many aspects of its clinical manifestations are not well understood. The aim of this work was to find the causes of the development of cognitive dysfunctions in individuals who had a mild form of SARS-CoV-2 using high-density EEG technology and solving an inverse neurophysiological problem. A dynamic study was conducted of 38 people who had COVID-19 and returned to work.

Immunogenicity and protectivity of intranasally delivered vector-based heterologous prime-boost COVID-19 vaccine Sputnik V in mice and non-human primates.

Although unprecedented efforts aiming to stop the COVID-19 pandemic have been made over the past two years, SARSCoV-2 virus still continues to cause intolerable health and economical losses. Vaccines are considered the most effective way to prevent infectious diseases, which has been reaffirmed for COVID-19. However, in the context of the continuing virus spread because of insufficient vaccination coverage and emergence of new variants of concern, there is a high demand for vaccination strategy amendment.

Structural Diversity of Silver Fluorinated β-Diketonates: Effect of the Terminal Substituent and Solvent.

In order to demonstrate the role of the fluorination and some solvents in the structural organization of the Ag(I) coordination polymers with β-diketonate ligands (RC(O)CHC(O)R) we synthesized a series of the compounds containing tfac- (R = CH, R = CF) and pfpac- (R = CH, R = CF) anions. Solvent-free [Ag(L)] (L = tfac , pfpac ) compounds and the corresponding acetonitrile and toluene adducts have been characterized by elemental analysis and/or NMR, IR and single-crystal XRD. This series includes five new coordination polymers.