Sodium-dependent glucose co-transport proteins (SGLTs) are not involved in human glucose taste detection.

The sweet taste of saccharides, such as sucrose and glucose, and other sweeteners is known to result from activation of the TAS1R2/R3 receptor expressed in taste receptor cells (TRCs) of the taste bud. Recent reports have suggested the existence of an additional sweet taste signaling pathway for metabolizable saccharides that is dependent on the activity of glucose transporters, especially SGLT1, also expressed in TRCs. We have investigated the potential contribution of SGLT1 to glucose taste signaling in humans.

Comb-Referenced Doppler-Free Spectrometry of the ^{200}Hg and ^{202}Hg Intercombination Line at 254 nm.

We report on precision spectroscopy of the 6s^{2} ^{1}S_{0}→6s6p ^{3}P_{1} intercombination line of mercury in the deep ultraviolet, by means of a frequency-comb referenced, wavelength-modulated, saturated absorption technique. This method allowed us to perform sub-Doppler investigations with an absolute frequency axis at 254 nm, while ensuring a relatively high signal-to-noise ratio. The absolute line center frequencies of the ^{200}Hg and ^{202}Hg bosonic isotopes were measured with a global uncertainty of 8 and 15 kHz (namely, 6.

Assessing Diabetic Retinopathy Staging With AI: A Comparative Analysis Between Pseudocolor and LED Imaging.

Purpose: To compare the diagnostic performance of artificial intelligence (AI)-based diabetic retinopathy (DR) staging system across pseudocolor, simulated white light (SWL), and light-emitting diode (LED) camera imaging modalities.

Methods: A cross-sectional investigation involved patients with diabetes undergoing imaging with an iCare DRSplus confocal LED camera and an Optos confocal, ultra-widefield pseudocolor camera, with and without SWL. Macula-centered and optic nerve-centered 45 × 45-degree photographs were processed using EyeArt v2.

From diagnosis to prognosis: A paradigm shift for multimodal imaging in assessing diabetic macular edema.

Diabetic macular edema (DME) is one of the leading causes of visual impairment in patients with diabetes. Multimodal imaging (MMI) has allowed a shift from DME diagnosis to prognosis. Although there are no accepted guidelines, MMI may also lead to treatment customization.

On the CH near-infrared spectrum: absolute transition frequencies and an improved spectroscopic network at the kHz accuracy level.

Lamb dips of twenty lines in the P, Q, and R branches of the ν + ν + ν vibrational band of CH, in the spectral window of 7125-7230 cm, have been measured using an upgraded comb-calibrated frequency-stabilized cavity ring-down spectrometer, designed for extensive sub-Doppler measurements. Due to the large number of carefully executed Lamb-dip experiments, and to the extrapolation of absolute frequencies to zero pressure in each case, the combined average uncertainty of the measured line-center positions is 15 kHz (5 × 10 cm) with a 2-σ confidence level. Selection of the twenty lines was based on the theory of spectroscopic networks (SN), ensuring that a large number of transitions, measured previously by precision-spectroscopy investigations, could be connected to the and principal components of the SN of CH.