Publications by authors named "S A Ghandhi"
In large-scale radiation exposure events, the ability to triage potential victims by the received radiation dosage is crucial. This can be evaluated by radiation-induced biological changes. Radiation-responsive mRNA is a class of biomarkers that has been explored for dose-dependency with methods such as RT-qPCR.
View Article and Find Full Text PDFAs the great majority of gene expression (GE) biodosimetry studies have been performed using blood as the preferred source of tissue, searching for simple and less-invasive sampling methods is important when considering biodosimetry approaches. Knowing that whole saliva contains an ultrafiltrate of blood and white blood cells, it is expected that the findings in blood can also be found in saliva. This human in vivo study aims to examine radiation-induced GE changes in saliva for biodosimetry purposes and to predict radiation-induced disease, which is yet poorly characterized.
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- There is a risk of many people being exposed to harmful radiation, either by accident or on purpose, which could lead to serious health problems.
- Scientists are exploring new ways to measure how much radiation each person absorbs using samples from their body, like blood.
- By using computers and different types of data from experiments on mice, researchers found that combining this data can help better understand and predict the effects of radiation exposure.
Tools for radiation exposure reconstruction are required to support the medical management of radiation victims in radiological or nuclear incidents. Different biological and physical dosimetry assays can be used for various exposure scenarios to estimate the dose of ionizing radiation a person has absorbed. Regular validation of the techniques through inter-laboratory comparisons (ILC) is essential to guarantee high quality results.
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- - The study focuses on developing new biodosimetry tests to accurately measure radiation exposure levels after nuclear accidents or attacks, emphasizing the need for reliable dose reconstruction regardless of exposure complexity.
- - Researchers examined the effects of varying radiation doses (0, 3, and 8 Gy) on mouse urine and serum metabolite profiles over two days following exposure, noting that both genders showed similar changes except for a few specific metabolites.
- - Results indicated that specific metabolite panels could effectively differentiate between lethal and sublethal radiation doses, suggesting potential for accurate identification of affected individuals in emergency situations.