Publications by authors named "S A Gerkowicz"
Study Question: Is reproductive aging in granulosa cells associated with markers of ovarian reserve?
Summary Answer: Age acceleration was associated with anti-Mullerian hormone (AMH) levels, antral follicle count (AFC), oocyte yield and maturity, and the number of successfully fertilized embryos.
What Is Known Already: The rate of reproductive aging varies among women of the same age. DNA methylation can be used to predict epigenetic age in a variety of tissues.
Ovarian reserve is an important determinant of a woman's reproductive potential, and women with diminished ovarian reserve (DOR) often seek in vitro fertilization (IVF). The underlying etiology of DOR is unknown, but follicular fluid cytokine concentrations likely play a role in follicular development and maturation. The present study seeks to investigate the expression of cytokines in follicular fluid (FF) of women with DOR undergoing IVF and explore correlated functional pathways.
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- The Oncofertility Consortium is an international initiative focused on addressing the reproductive concerns of cancer patients, individuals transitioning genders, and others facing treatments that may affect fertility.
- The consortium operates as a community of practice, sharing knowledge and strategies among specialists from various fields to improve healthcare outcomes and quality of life for patients.
- Their ongoing mission is to combine scientific advancements with patient needs, aiming to create a supportive network that adapts to future challenges in reproductive health and survivorship.
Article Synopsis
- Michigan residents faced health risks after polybrominated biphenyls (PBBs) were accidentally mixed into the food supply, leading to different health problems in men and women.
- A study analyzed DNA methylation using samples from 381 women and 277 men with PBB exposure, revealing 675 methylation sites in men but only 17 in women, with no overlap between the sexes.
- The findings suggest that PBB exposure affects the epigenome differently for men and women, potentially explaining the distinct adverse health effects observed in each sex.
In 1973, accidental contamination of Michigan livestock with polybrominated biphenyls (PBBs) led to the establishment of a registry of exposed individuals that have been followed for > 40 years. Besides being exposed to PBBs, this cohort has also been exposed to polychlorinated biphenyls (PCBs), a structurally similar class of environmental pollutants, at levels similar to average US exposure. In this study, we examined the association between current serum PCB and PBB levels and various female reproductive health outcomes to build upon previous work and inconsistencies.
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