Targeting the ATF6-Mediated ER Stress Response and Autophagy Blocks Integrin-Driven Prostate Cancer Progression.

Unlabelled: Prostate cancer progression to the lethal metastatic castration-resistant phenotype (mCRPC) is driven by αv integrins and is associated with Golgi disorganization and activation of the ATF6 branch of unfolded protein response (UPR). Overexpression of integrins requires N-acetylglucosaminyltransferase-V (MGAT5)-mediated glycosylation and subsequent cluster formation with Galectin-3 (Gal-3). However, the mechanism underlying this altered glycosylation is missing.

The non-canonical mechanism of ER stress-mediated progression of prostate cancer.

Background: The development of persistent endoplasmic reticulum (ER) stress is one of the cornerstones of prostate carcinogenesis; however, the mechanism is missing. Also, alcohol is a physiological ER stress inducer, and the link between alcoholism and progression of prostate cancer (PCa) is well documented but not well characterized. According to the canonical model, the mediator of ER stress, ATF6, is cleaved sequentially in the Golgi by S1P and S2P proteases; thereafter, the genes responsible for unfolded protein response (UPR) undergo transactivation.

[Decrease in time of transurethral laser litotripsy due to micro-drainage applications].

Introduction: The length of the operation to remove urinary concernments has a marked effect on the occurrence of postoperative complications in the time of the postoperative patients in the hospital. A significant factor contributing to the increase in time is the clouding of the fragmentation region, which increases the operation time and the number of complications.

Purpose: to develop a method of reducing the time of additional costs in contact lithotripsy with a holmium laser in order to reduce the risk of postoperative complications.

[The assesment of the fragmentation rate of urinary stones during the holmium laser lithotripsy].

Introduction: For rational planning of laser lithotripsy tactics, determination of pulse settings and laser modes, considering patients condition, stone size and composition as well as for more rationale planning of operation theatre loading and the use of high-technology equipment the knowledge of the time required for complete stone fragmentation is needed. It is still assessed subjectively base on the urologists own experience.

Aim: To determine the specific value of urinary stones mass decrease in order to evaluate exact time for complete fragmentation during holmium laser lithotripsy.

[Prognosis of rotavirus infection in children].

The aim of the research was to develop the method for predicting the course of rotavirus gastroenteritis in children.Under the supervision were 3607 children aged from 9 days to 5 years with the diagnosis of "Acute gastroenteritis" and "Acute gastroenterocolitis". The diagnosis of rotavirus infection was on the basis of a set of clinical, epidemiological data and the results of para-clinical and bacteriological studies and data of detection of rotavirus antigen strain.