In-vitro study of the radioprotective effect of palladium α-lipoic acid nano-complex on hemoglobin molecule.

This work is intended to study the radioprotective effect of palladium α-lipoic acid nano-complex (PLAC) on hemoglobin molecule in vitro. Blood samples were obtained from adult male rats weighing 120-150 g after dissection, using heparinized needles. Each blood sample was divided into four groups; the first group was kept untreated as control, palladium α-lipoic acid (PLAC) was added to the second group at concentration 2% v/v, the third group was exposed to 100 Gy gamma radiation and the forth group was irradiated with the addition of PLAC.

Ameliorative effects of rutin on hepatic encephalopathy-induced by thioacetamide or gamma irradiation.

Hepatic encephalopathy (HE) is a syndrome resulting from acute or chronic liver failure. This study was designed to evaluate the effect of rutin on thioacetamide (TAA) or γ-radiation-induced HE model. Animals were received with TAA (200mg/kg, i.

Radiation-induced changes in the optical properties of hemoglobin molecule.

Adult male Albino rats were exposed to different doses of gamma radiation from Cs-137 source. Hemoglobin samples were analyzed 24 h after irradiation. The UV-visible spectrum of hemoglobin molecule was measured in the range 200-700 nm.

Biophysical characterization of beta-thalassemic red blood cells.

Thalassemia is the world's most common hereditary disease; therefore, more interest has been devoted for the development of the screening procedure of this disease. In beta-thalassemia major, the subject of the current study, impaired biosynthesis of beta-globin leads to accumulation of unpaired alpha-globin chain. The objective of the present study, was to examine many of the biophysical properties of beta-thalassemia major red blood cells (RBCs) and to study the possibility of use of any of them as a preliminary screening tool for beta-thalassemia.

NMR characterization of an S-linked glucuronide metabolite of the potent, novel, nonsteroidal progesterone agonist tanaproget.

Tanaproget is a first-in-class nonsteroidal progesterone receptor agonist that is being investigated for use in contraception. A major in vitro and in vivo metabolite of tanaproget formed in humans was initially characterized as a glucuronide of tanaproget. However, whether the glucuronide was linked to the nitrogen or sulfur of the benzoxazine-2-thione group in tanaproget could not be determined by liquid chromatography/mass spectrometry (LC/MS) and LC-tandem mass spectrometry analysis.