A Novel Technique for Femoral Stem Extraction Through the Direct Anterior Approach: The Medial Episiotomy With Anterior Transfemoral Osteotomy.

This report describes a medial calcar episiotomy with partial anterior transfemoral osteotomy of the proximal femur to aid in removal of a femoral component in setting of revision total hip arthroplasty through a direct anterior approach. Revision total hip arthroplasty is challenging, labor-intensive, and carries high complication rates. Previously described techniques such as extended trochanteric osteotomies can be utilized to facilitate removal of fixed femoral stems.

Sex Differences and Extracorporeal Shockwave Therapy Outcomes in Runners with Achilles or Hamstring Tendinopathy.

: Achilles and hamstring tendinopathies are common injuries in runners, and extracorporeal shockwave therapy (ESWT) may be an effective treatment. Runners are at risk for lower extremity tendinopathies and the Male and Female Athlete Triad (Triad). The purpose of this study is to evaluate the association of sex, exposure to hormonal contraceptives, menopause, and Triad-related risk factors with ESWT outcomes in the treatment of Achilles and hamstring tendinopathy.

Clinical use of ACQUIRE Therapy for Children Diagnosed With CASK-Gene Related Disabilities.

Objective: To report practice based evidence built on clinical findings where an intensive therapeutic approach called ACQUIRE Therapy was used as a rehabilitation/habilitation tool for children diagnosed with CASK mutations. ACQUIRE Therapy delivery is based on principles of learning and guided by a therapeutic framework often used in the delivery of intensive therapy.

Design: Clinical Cohort.

Engineered Cardiac Tissues as a Platform for CRISPR-Based Mitogen Discovery.

Improved understanding of cardiomyocyte (CM) cell cycle regulation may allow researchers to stimulate pro-regenerative effects in injured hearts or promote maturation of human stem cell-derived CMs. Gene therapies, in particular, hold promise to induce controlled proliferation of endogenous or transplanted CMs via transient activation of mitogenic processes. Methods to identify and characterize candidate cardiac mitogens in vitro can accelerate translational efforts and contribute to the understanding of the complex regulatory landscape of CM proliferation and postnatal maturation.

Engineered myovascular tissues for studies of endothelial/satellite cell interactions.

In native skeletal muscle, capillaries reside in close proximity to muscle stem cells (satellite cells, SCs) and regulate SC numbers and quiescence through partially understood mechanisms that are difficult to study in vivo. This challenge could be addressed by the development of a 3-dimensional (3D) in vitro model of vascularized skeletal muscle harboring both a pool of quiescent SCs and a robust network of capillaries. Still, studying interactions between SCs and endothelial cells (ECs) within a tissue-engineered muscle environment has been hampered by the incompatibility of commercially available EC media with skeletal muscle differentiation.