A preclinical study of diffusion-weighted MRI contrast as an early indicator of thermal ablation.

Purpose: Intraoperative T -weighted (T2-w) imaging unreliably captures image contrast specific to thermal ablation after transcranial MR-guided focused ultrasound surgery, impeding dynamic imaging feedback. Using a porcine thalamotomy model, we test the unproven hypothesis that intraoperative DWI can improve dynamic feedback by detecting lesioning within 30 minutes of transcranial MR-guided focused ultrasound surgery.

Methods: Twenty-five thermal lesions were formed in six porcine models using a clinical transcranial MR-guided focused ultrasound surgery system.

Pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories and oral syrup to healthy subjects.

The pharmacokinetics of promethazine hydrochloride after administration of rectal suppositories at three dosage strengths and oral syrup were studied. The study had an open-label, randomized, crossover design. At intervals of five to nine days, healthy volunteers were given two 12.

The influence of bromfenac on the pharmacokinetics and pharmacodynamic responses to glyburide in diabetic subjects.

Study Objective: To assess the effect of bromfenac sodium, a nonnarcotic analgesic drug under development, on the pharmacokinetics and pharmacodynamics of glyburide in patients with type II diabetes.

Design: Randomized, double-blind, placebo-controlled, multiple-dose study with a two-period crossover design.

Patients: Eleven men and one woman (age 36-64 yrs) whose diabetes was responsive to oral sulfonylurea therapy.

Effects of age and gender on the pharmacokinetics of bromfenac in healthy volunteers.

Objective: To compare the pharmacokinetic parameters of bromfenac, a nonsteroidal antiinflammatory drug under development, in healthy volunteers of various ages and either gender, after single and multiple doses.

Design: Open-label, single- and multiple-dose, nonrandomized, parallel study.

Participants: Twenty young (18-45 y), 12 young-elderly (65-74 y), and 12 elderly (75-85 y) subjects were studied.

Absolute bioavailability of bromfenac in humans.

Objective: To estimate absolute bioavailability of bromfenac and to compare its pharmacokinetics after intravenous and oral administration.

Design: This was a randomized, open-label, single-dose, crossover study conducted under fasting conditions with a washout period of at least 48 hours between doses. Each subject received a 50-mg dose of bromfenac both intravenously and orally followed by collection of blood samples at specified time intervals.