Integration of 168,000 samples reveals global patterns of the human gut microbiome.

The factors shaping human microbiome variation are a major focus of biomedical research. While other fields have used large sequencing compendia to extract insights requiring otherwise impractical sample sizes, the microbiome field has lacked a comparably sized resource for the 16S rRNA gene amplicon sequencing commonly used to quantify microbiome composition. To address this gap, we processed 168,464 publicly available human gut microbiome samples with a uniform pipeline.

School Ethnic Density and Mental Health Problems in Black, Latine, and White Preadolescent Children.

Objective: Previous studies suggest school ethnic density is associated with less internalizing problems in Black and Latine adolescents in high school. Here, we assessed associations between school ethnic density and internalizing, externalizing, and thought problems in Black, Latine, and White pre-adolescent children (mean age=9.9 years) in elementary school.

Profiles of testosterone and pre-androgens and sexual function in premenopausal women.

Background: There is inconsistent evidence as to the role of testosterone and pre-androgens in premenopausal female sexual function, and reported associations between blood concentrations of these hormones and female sexual function vary in strength.

Aim: To examine the patterns of testosterone and pre-androgen concentrations and variations in sexual function in premenopausal eumenorrheic women.

Methods: This was a secondary analysis of a sample of 588 premenopausal eumenorrheic women from the Grollo-Ruzzene Foundation Young Women's Health Study.