Publications by authors named "S A Chandrika N Perera"
Vaccinating children with disability in low- and middle-income countries, such as Fiji, is a key priority for equity. This study aimed to understand the social and behavioral drivers of vaccine uptake among children with disability in Fiji, from the perspectives of health, disability, and community stakeholders. Five qualitative focus groups were conducted with 22 stakeholders, including healthcare workers, disability service providers and advocates, and community and faith leaders (female n = 17, 77%).
View Article and Find Full Text PDFTriple-negative breast cancer (TNBC) is a highly aggressive and clinically challenging subtype of breast cancer, lacking the expression of estrogen receptor (ER), progesterone receptor (PR), and HER2/neu. The absence of these receptors limits therapeutic options necessitating the exploration of novel treatment strategies. Epigenetic modifications, which include DNA methylation, histone modifications, and microRNA (miRNA) regulation, play a pivotal role in TNBC pathogenesis and represent promising therapeutic targets.
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- The study examined the causes and outcomes of acute kidney injury (AKI) in 464 patients at a tertiary care center in Sri Lanka, highlighting the influence of age, comorbidities, and severity on patient prognosis.
- Of the patients, 56.5% were male, with a mean age of 57.04 years; by 90 days, most patients showed improvement in renal function, though mortality rates were highest in those over 60 and with more severe AKI.
- The research identified major challenges in AKI management, including inadequate resources and infrastructure, underscoring the importance of early identification and intervention for at-risk populations.
Article Synopsis
- The study aimed to determine if the structure and biomechanics of neural tissue can predict functional loss in glaucoma and to assess the role of biomechanics in improving prediction accuracy.
- Researchers gathered data from 238 glaucoma patients over 50 years old, using advanced imaging techniques to analyze the optic nerve head under different pressure conditions.
- Results showed that incorporating biomechanical data significantly improved prediction performance (F1-score: 0.76) compared to using only structural information (F1-score: 0.71), highlighting the importance of biomechanics in assessing glaucoma severity.*