[The immunological activity of Neisseria meningitidis lipo-oligosaccharide incorporated into liposomes].

Immune response to lipooligosaccharide (LOS), isolated from group B N. meningitidis cell wall, was studied after its incorporation into liposomes. The adjuvant effect produced by liposomal LOS, more pronounced in comparison with that produced by native LOS, was observed after the injection of the preparation by different routes (intravenous, intraperitoneal and subcutaneous injections), but the highest level of response was achieved after the intravenous and intraperitoneal injections of the preparation.

[Autologous liposomes].

A possibility to increase liposomal tropism to different organs by obtaining them from target lipid cells is considered. The interaction of liposomes of varying phospholipid and ganglioside composition with hepatic cells of rats was studied in vitro. It was found that this interaction was governed both by the phospholipid and ganglioside composition of the vesicles.

[Protective action of liposome-incorporated surface antigens of the influenza virus by different methods of immunization].

The influence of different routes of immunization on the protective effect of liposome-incorporated influenza A/PR/8/34 virus surface antigens was studied. Influenza virus surface antigens, neuraminidase and hemagglutinin, incorporated into liposomes, were shown to have a significant protective effect upon intraperitoneal and intranasal administration against a lethal dose of influenza virus as compared with immunization using a free antigen solution against the same infection. The protective effect is poor in intravenous immunization with influenza virus antigen-containing liposomes.