Hemoglobin Isoforms in Rat Erythrocytes in Acute Aseptic Inflammation.

Qualitative rearrangement in erythropoiesis (changes in the ratio between erythrocyte populations and hemoglobin isoforms) was revealed in male Wistar rats with modeled acute aseptic inflammation. It was found that the percentage of heavy hemoglobin isoforms prevailed over the light forms in the bloodstream. Deciphering of the mechanisms of these changes requires additional research.

Physical Activity and Aging: Exploring Motivations of Masters Swimmers.

Physical activity benefits the health of older adults (e.g., lowering risk of cardiovascular disease, depression, dementia, and falls).

Changes in Hemoglobin Isoforms in the Peripheral Blood of Rats with Experimental Posthemorrhagic Anemia.

Six hemoglobin isoforms were identified in the peripheral blood of male Wistar rats by PAAG electrophoresis. Erythrocytes can be separated into 6 fractions by fractional centrifugation; the fractions differ by the content of reticulocytes and cells with fetal hemoglobin. Cells in each fraction contain one light and one heavy hemoglobin isoforms, and their combination is specific to each fraction.

Effects of 1,3,4-thiadiazine compound with antidepressant properties in ligation model of acute pancreatitis.

Based on hypotheses concerning the role of stress in acute pancreatitis development, the experimental approach for the decrease stress damage via the use the compound with proven antistress/neuroleptic action was conducted. The study was aimed to discover 2-morpholino-5-phenyl-6H-1,3,4-thiadiazine hydrobromide (compound L-17) therapeutic action in experimental acute pancreatitis. The experimental model used was the ligation model.

The impact of immunomodulator compound from the group of substituted thiadiazines on the course of stress reaction.

A significant role of the stress response to many different diseases prompted a search for new specialized and non-specialized anti-stress agents. This study examines the effect of the compound L17 from the group of 5-phenyl substituted-6H-1,3,4-thiadiazine-2-amines, on the manifestations of the stress response. The authors used a standard model of immobilization stress, in which an animal was immobilized on its back for 6h a day.