Human iPSC derived organoid models to study tau pathology.

Background: Human pluripotent stem cell (hPSC)‐derived brain organoids patterned towards the cerebral cortex are valuable models of interactions occurring in cortical tissue. We and others have used these cortical organoids to model dominantly inherited FTD‐tau. While these studies have provided essential insights, cortical organoid models have yet to reach their full potential.

Method of accessing alcohol and binge drinking status in youth and young adults.

Aims: The study investigated relationships between how youth and young adults access alcohol and their binge drinking behaviors.

Methods: Data from the Rhode Island Student Survey (11- to 18-year-olds) and the Mobile Screen Time project (18- to 24-year-old) were included. Participants were asked whether they access alcohol through several different methods (e.

Stability of Volatile Organic Compounds in Thermal Desorption Tubes and in Solution.

Exhaled breath VOCs are often collected and stored in sorbent tubes before thermal desorption-gas chromatography-mass spectrometry (TD-GC-MS) analysis. Information about the stability of VOCs during storage is needed to account for potential artifacts and monitor for losses. Additionally, information about the stability of VOC standards in solution is required to assess their performance as quality control and internal standards.

Statewide Trends in Medications for Opioid Use Disorder Utilization in Rhode Island, United States, 2017-2023.

Background: Buprenorphine and methadone are US Food and Drug Administration-approved medications for opioid use disorder (MOUD). Although utilization of MOUD was increasing pre-COVID-19, it is not well understood how this trend shifted during and "after" the COVID-19 pandemic in Rhode Island. This analysis will consider the differential utilization of MOUD over time and by key demographic factors.

Project SUCCESS: Youth Substance use and Mental Health.

This study aims to assess whether students at schools implementing Project SUCCESS (PS) have different substance use and mental health outcomes than those at schools not implementing PS. Surveys were administered to 18,151 middle and high school students from 29 school districts and 50 schools. Multivariable logistic and linear regressions controlling for individual- and school-level characteristics were used.