Dose related induction of the drug metabolizing enzymes of rat liver by cilobamine.

Cilobamine , an antidepressant, was investigated for its influence on the hepatic drug metabolizing enzymes ( DME ) of male Charles River CD rats. Cilobamine doses (3, 10, 30, 100, and 300 mg/kg po, as free base) were compared to sodium phenobarbital (PB) doses (3, 10, 30, 100, and 200 mg/kg po, as free acid). Compounds were given daily for 4 days and all tests were done on Day 5.

Metabolic disposition of terfenadine in laboratory animals.

Alpha-[4-(1,1-Dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1- piperidinebutanol (terfenadine, RMI 9918, Triludan, Teldane, resp.), a clinically effective antihistamine, with little or no central nervous system effects, was investigated in order to understand its metabolic disposition. These 14C-terfenadine studies were performed in laboratory animals, principally the rat, and also in beagle dog and monkey (Macaca mulatta).

Bioavailability of terfenadine in man.

Fourteen normal male subjects were given either 60mg or 180mg of terfenadine suspension in a randomized two-way crossover study. Peak plasma concentrations of 1.544 +/- 0.

Decrease in the activity of the drug-metabolizing enzymes of rat liver following the administration of tilorone hydrochloride.

Tilorone hydrochloride, 2,7-bias(2-(diethylamino)ethoxy(fluoren-9-one dihydrochloride, has been studied to determine its effect on the drug-metabolizing enzymes of the liver of male Charles River CD strain rats. Single and multiple doses of tilorone-HCl, 100 mg/kg/day po, were used. Most experiments were performed 24 hr after the last dose, except for a study 5 hr after dosing, and those in which the duration of effects of tilorone hydrochloride were determined.