Publications by authors named "S A Athanaselis"
Purpose: Τhe aim of the present study was to investigate the use of vitreous humor as an alternative biological material in forensic toxicology for the determination of quetiapine, 7-hydroxy-quetiapine, and nor-quetiapine. The distribution of these substances in vitreous humor was studied by determining and correlating their concentrations in vitreous humor with the respective concentrations in blood.
Methods: During this study, a method for the determination of these substances was developed, validated and applied to postmortem samples obtained from 16 relative forensic cases.
Purpose: Serum and urinary bisphenol A (BPA) concentrations have been associated negatively with the number of retrieved oocytes after in vitro fertilization (IVF). The impact of BPA upon women with polycystic ovary syndrome (PCOS) and women with tubal factor infertility (TFI), following IVF, was investigated. To this purpose, associations among serum and urinary and follicular fluid (FF) BPA concentrations and the number of retrieved and fertilized oocytes and comparisons between pregnancy rates were evaluated.
View Article and Find Full Text PDFVitreous humor has become in recent years an important alternative biological fluid in forensic toxicological analysis especially for the investigation of cases where alcohol and drugs of abuse are involved but there is limited scientific information regarding the distribution of antidepressant drugs in this material. This work aimed to study the distribution of antidepressant drugs in vitreous humor and to estimate the blood/vitreous humor concentration ratios of these drugs. For this purpose, a GC/MS method for the simultaneous determination of 9 antidepressant drugs, namely amitriptyline, nortriptyline, citalopram, clomipramine, fluoxetine, maprotiline, mirtazapine, sertraline and venlafaxine, and 4 of their metabolites, namely desmethylmaprotiline, desmethylmirtazapine, desmethylsertraline, O-desmethylvenlafaxine, was developed and validated.
View Article and Find Full Text PDFObjective: To develop and validate a simple reversed-phase HPLC method for the quantitation and evaluation of stability of α-lipoic acid in cosmetics, according to International Conference on Harmonization (ICH) Guidelines.
Methods: The chromatography was performed on a reversed-phase Luna C18, analytical column (150 × 4.6 mm id, 5 μm particle size) with a mobile phase of potassium dihydrogen phosphate (pΗ 4.
Article Synopsis
- Driving under the influence of alcohol and psychoactive substances significantly raises the chances of fatal motor vehicle accidents, with a study analyzing data from 2011 to 2017.
- Out of 1,841 fatal accident autopsies, 40.7% involved alcohol, predominantly affecting male drivers under 30 with high blood alcohol concentrations.
- Additionally, 18.9% of victims tested positive for psychoactive substances, with cannabis being the most common, indicating that both alcohol and drugs are critical risk factors in road traffic fatalities.