Publications by authors named "S A Amiel"
Context & Objective: Sparse large-scale studies have characterized hypoglycemia symptomatology in adults with type 1 diabetes (T1D) who use continuous glucose monitoring (CGM). This research aimed to evaluate the relationship of impaired awareness of hypoglycemia (IAH) with hypoglycemia symptomatology and frequency in this population.
Design: A cross-sectional survey was conducted in 2023.
Aims/hypothesis: We aimed to: (1) externally validate the five-item Hypoglycaemia Awareness Questionnaire (HypoA-Q) impaired awareness subscale (HypoA-Q IA); (2) examine how impaired awareness of hypoglycaemia (IAH) relates to the risk of severe hypoglycaemia and level 2 hypoglycaemia; and (3) identify factors associated with IAH.
Methods: Nationwide survey of T1D Exchange registrants was conducted to collect data on demographics, 6 month severe-hypoglycaemia history, hypoglycaemia awareness status (via HypoA-Q IA, the Gold instrument and the Clarke instrument) and continuous glucose monitor (CGM) measures. The Clarke hypoglycaemia awareness factor (Clarke-HAF) was calculated to exclude severe-hypoglycaemia history items.
Article Synopsis
- The Hypo-METRICS study explored how continuous glucose monitoring (CGM) detects hypoglycemia and its relevance for people with type 1 and insulin-treated type 2 diabetes.
- Researchers tracked 276 type 1 and 321 type 2 diabetes participants using CGM for 10 weeks, correlating sensor-detected hypoglycemia (SDH) with person-reported hypoglycemia (PRH).
- Results indicated that a significant portion of CGM-detected hypoglycemia is asymptomatic, with 65% of low readings (under 70 mg/dL) not accompanied by symptoms and many reported symptoms occurring at higher glucose levels (over 70 mg/dL).
Aim: To examine the hypothesis that there would be ethnic differences in the relationship between ectopic fat and tissue-specific insulin resistance (IR) across a spectrum of glucose tolerance in Black African (BA) and White European (WE) men.
Materials And Methods: Fifty-three WE men (23/10/20 normal glucose tolerance [NGT]/impaired glucose tolerance [IGT]/type 2 diabetes [T2D]) and 48 BA men (20/10/18, respectively) underwent a two-step hyperinsulinaemic-euglycaemic clamp with infusion of D-[6,6-H]-glucose and [H]-glycerol to assess hepatic, peripheral and adipose tissue IR. Magnetic resonance imaging was used to measure subcutaneous adipose tissue, visceral adipose tissue (VAT) and intrahepatic lipid (IHL).
Article Synopsis
- The study aimed to explore how experiencing hypoglycemia affects daily life in adults with type 1 and insulin-treated type 2 diabetes using the Hypo-METRICS app over 70 days.
- Participants reported their hypoglycemia experiences through daily check-ins while wearing a glucose sensor that provided data without their knowledge.
- Results indicated that self-reported hypoglycemia negatively impacted energy, mood, cognitive function, and sleep quality, while sensor-detected hypoglycemia alone did not show these associations.