Publications by authors named "S A Al-Othman"
Article Synopsis
- A new core-shell nanostructure combining zinc-phosphate and hydroxyapatite (ZP/HP) was developed and enhanced using chitosan and β-cyclodextrin, improving its properties for drug delivery.
- *The modified structures showed significantly better loading capacity for the cancer drug 5-fluorouracil, with rates reaching up to 342.8 mg/g compared to the original 238.9 mg/g of ZP/HP.
- *These functionalized carriers not only released the drug more effectively over time but also increased its toxicity against colorectal cancer cells, with much lower cell viability observed in the presence of the modified compounds.*
The uncontrolled administration of the cisplatin drug (CPTN) resulted in numerous drawbacks. Therefore, effective, affordable, and biocompatible delivery systems were suggested to regulate the loading, release, and therapeutic effect of CPTN. Zinc phosphate/hydroxyapatite hybrid form (ZP/HP) and core-shell nano-rod morphology, as well as its functionalized derivative with cellulose (CF@ZP/HP), were synthesized by the facile dissolution precipitation method followed by mixing with cellulose fibers, respectively.
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- The text indicates there is a correction to a previously published research article, identified by its Digital Object Identifier (DOI).
- The DOI number 10.1039/D4RA02144D is likely referencing a specific article in scientific literature, which may have contained inaccuracies or errors that needed to be addressed.
- The correction aims to clarify or amend the original findings to ensure accurate dissemination of information in the field.
An advanced form of magnesium-rich hydroxyapatite (Mg·HAP) was modified with two types of biopolymers, namely chitosan (CH/Mg·HAP) and β-cyclodextrin (CD/Mg·HAP), producing two types of bio-composites. The synthesized materials were developed as enhanced carriers for levofloxacin to control its loading, release, and anti-inflammatory properties. The polymeric modification significantly improved the loading efficiency to 281.
View Article and Find Full Text PDFAims: In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Using proteomics, this study aimed to dissect the protein and phosphorylation remodelling within the sinus node in an animal model of HF with concurrent SND.
Methods And Results: We acquired deep sinus node proteomes and phosphoproteomes in mice with heart failure and SND and report extensive remodelling.