[The diagnosis of idiopathic epilepsy in children based on the algorithm of molecular-genetic studies].

Aim: To study mutations and polymorphisms in the sodium channels genes, determining the development of idiopathic epilepsy (IE).

Material And Methods: The study of SCN1A gene by direct Sanger sequencing in 53 patients and targeted resequencing of the regions of 34 genes in 40 patients with different clinical forms of IE was performed.

Results: Seven mutations (c.

[Etiology of "difficult" laparoscopic cholecystectomy].

Aim: To define causes of difficult situations in various forms of acute cholecystitis depending on terms of disease and clinico-morphological changes in gall bladder area and to justify differentiated application of laparoscopic surgery for acute cholecystitis.

Material And Methods: It was reviewed 1132 medical records of patients with acute cholecystitis. It is found that morphological changes in gall bladder and surrounding tissues depend on duration of follow-up of patients with acute cholecystitis and type of inflammation.

[The retrospective study of efficacy and safety of levetiracetam as an add-on treatment of epilepsy in children].

The objective was to retrospectively study the efficacy and safety of levetiracetam (keppra) as an add-on treatment of pharmacoresistant forms of epilepsy in children. We have analyzed medical histories of 192 patients with pharmacoresistant epilepsy admitted to a neurological department of the Research and Treatment Center of Children's Medical Care over the period of 2008-2011. The patient's age varied in the range from 6 months to 19 years (mean age 5.

[Video-EEG monitoring in the diagnosis of epilepsy in children].

This paper analyzes the results of a survey of 785 patients referred to our hospital with a diagnosis of epilepsy. Diagnosis of forms of epilepsy and definition of the localization of epileptogenic focus in patients with focal epilepsy (FE) were performed using the method of video-EEG monitoring. Every fifth patient with suspected ongoing seizures has nonepileptic paroxysms.