Publications by authors named "S A Abraham"

Background: The prevalence of ulcerative colitis (UC) is around 200/100 000 people. Colectomy is required in 7.5%-40% of patients and 58.

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Background & objectives Alkaptonuria (AKU) is an autosomal recessive disease wherein biallelic pathogenic variants in the homogentisate 1,2- dioxygenase (HGD) gene encoding the enzyme homogentisate 1,2 dioxygenase cause high levels of homogentisic acid (HGA) to circulate within the body leading to its deposition in connective tissues and excretion in urine. A homozygous splice donor variant (c.87+1G>A) has been identified to be the founder variant causing alkaptonuria among Narikuravars, a group of gypsies settled in Tamil Nadu.

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Background: Guidelines recommend palliative care (PC) for patients with heart failure. However, little research has been performed assessing the effect of PC consultation in patients with heart failure with preserved ejection fraction (HFpEF).

Objectives: The purpose of this study was to investigate the impact of PC consultation on symptom burden and health care utilization among individuals with HFpEF during the last 3 years of their lives.

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Background: Acute pancreatitis (AP) is a major health threat, with a high mortality rate in severe forms. Though alcohol and bile-induced factors are the most common causes, increasing evidence suggests that viral infections such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human immunodeficiency virus (HIV) may also trigger AP development. Our study aims to explore this association in greater detail.

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Article Synopsis
  • The study compared three techniques for ERCP (endoscopic retrograde cholangiopancreatography) in patients who had undergone Roux-en-Y gastric bypass: enteroscopy-assisted (EA-ERCP), laparoscopy-assisted (LA-ERCP), and endoscopic ultrasound-directed (EDGE).
  • 67 studies were analyzed, showing that EDGE had the highest technical success rate at 96%, followed by LA-ERCP at 93%, and EA-ERCP at 77%, with significant differences between EA-ERCP and the other methods.
  • The overall rates of adverse events were similar across all techniques, suggesting that EDGE and LA-ERCP are both effective and as safe
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