Publications by authors named "S -y. Okazaki"
Objectives: The feasibility of corticosteroid withdrawal (CW) for Takayasu arteritis (TAK) remains uncertain. Two autoantibodies (Abs) are identified against endothelial protein C receptor (EPCR) and scavenger receptor class B type 1 (SR-BI) in TAK, determining its three subgroups. This study aimed to evaluate CW using tocilizumab (TCZ) and its association with the Ab profile.
View Article and Find Full Text PDFLike the lines themselves, concerns about facial wrinkles, particularly glabellar lines - the prominent furrows between the eyebrows - intensify with age. These lines can inadvertently convey negative emotions due to their association with negative facial expressions. We investigated the effects of repeated frowning on the development of temporary glabellar lines through the activation of the corrugator muscle.
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- Pancreatic ductal adenocarcinomas (PDAC) are highly aggressive and lack effective treatments; this study examines potential new therapies using rat monoclonal antibodies (mAbs) targeting specific membrane proteins.
- Key membrane proteins such as HER1-4, MET, S1PR1, LAT1, and CD44v are frequently expressed in PDAC, and targeting them with mAbs demonstrated growth inhibition in various cancer cell lines.
- High levels of CD44v in PDAC correlate with poor patient prognosis, indicating that targeting CD44v and related proteins could provide new diagnostic and therapeutic avenues for treating this aggressive cancer.
The purpose of this study was to construct an artificial intelligence object detection model to detect the articular disk from temporomandibular joint (TMJ) magnetic resonance (MR) images using YOLO series. The study included two experiments using datasets from different MR imaging machines. A total of 536 MR images were retrospectively examined.
View Article and Find Full Text PDFObjective: This study aimed to evaluate the quality of life (QOL) in children with epilepsy and their caregivers, as well as the caregiver burden, through a secondary analysis of a cross-sectional online survey in Japan.
Methods: Eligible participants were caregivers of children (aged < 18 years) diagnosed with epilepsy. Children's QOL was measured using the daily living subset of the Japanese version of the Quality of Life in Children with Epilepsy (QOLCE-Js52).