Inter-domain interaction of ferredoxin-NADP+ reductase important for the negative cooperativity by ferredoxin and NADP(H).

Ferredoxin-NADP+ reductase (FNR) in plants receives electrons from ferredoxin (Fd) and converts NADP+ to NADPH. The affinity between FNR and Fd is weakened by the allosteric binding of NADP(H) on FNR, which is considered as a part of negative cooperativity. We have been investigating the molecular mechanism of this phenomenon and proposed that the NADP(H)-binding signal is transferred to the Fd-binding region across the two domains of FNR, NADP(H)-binding domain and FAD-binding domain.

Chronic diverticulitis of the large intestine characterized by stenosis symptoms in Japan: report of 6 cases.

The concept of chronic diverticulitis, which is characterized by stenosis symptoms, has recently been proposed. However, it is not widely known in Japan. To stress the prevalence of this disease in Japan, we herein report 6 patients with chronic diverticulitis who required surgery.