Publications by authors named "Ryuta Sato"

Background: Oral hypofunction is the stage before oral dysfunction. The subjective symptoms of poor oral function and the decline in oral health-related quality of life (OHRQoL) that occur in the oral hypofunction stage can be missed.

Objective: This multicentre cross-sectional study was performed to examine the relationships between the test results for oral hypofunction, subjective frailty symptoms and OHRQoL of outpatients in dental clinics.

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  • - This study analyzed the impact of different dental prosthetic methods on patients with Kennedy Class I partial edentulism, focusing on aspects like oral function, frailty symptoms, and quality of life.
  • - 348 patients were divided into three groups: those with natural teeth (NT), those using removable partial dentures (RPD), and those with implant-supported fixed prostheses (ISFP), and their oral health was evaluated through various tests and questionnaires.
  • - Results indicated that the RPD group experienced poorer oral hygiene, reduced chewing ability, and higher rates of frailty symptoms compared to the ISFP group, suggesting that the type of prosthetic method significantly influences patients' oral health outcomes.
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  • A 71-year-old man experienced a life-threatening hypercalcemic crisis due to primary hyperparathyroidism caused by a parathyroid adenoma.
  • Standard treatment typically involves early hemodialysis or hemodiafiltration with low-calcium solutions, but this patient was successfully treated with continuous hemodialysis using regular calcium concentration dialysate.
  • After the patient's condition improved, a parathyroidectomy was performed, leading to his recovery; this case highlights the importance of timely intervention and the need for effective management strategies in similar crises.
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  • The study aimed to analyze real-world outcomes for penile cancer patients in the Kyushu-Okinawa area before Japan's practice guidelines were introduced, using data from January 2009 to December 2020.
  • A total of 196 patients with varying clinical stages of penile squamous cell carcinoma were included, showing a median follow-up of 26 months and five-year overall and cancer-specific survival rates of 74.3% and 79.8%, respectively.
  • The research identified key independent prognostic factors affecting survival, such as clinical node involvement (cN ≥ 2), performance status (Eastern Cooperative Oncology Group ≥ 1), and tumor stage (cT ≥ 3), highlighting the need for further studies on penile
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Background: It is crucially important to understand the risk factors for rectal bleeding after volumetric-modulated arc radiotherapy (VMAT) for prostate cancer to prevent subsequent rectal bleeding. We assayed clinical and dosimetric data to investigate the risk factors for rectal bleeding after VMAT of prostate cancer.

Materials And Methods: This study included 149 patients with prostate cancer who received VMAT from February, 2012 to June, 2020.

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Non-adherent cells, such as hematopoietic cells and lymphocytes, are important research subjects in medical and biological fields. Therefore, a system that enables the handling of non-adherent cells in solutions in the same manner as that of adhering cells during medium exchange, exposure to chemicals, washing, and staining in imaging applications would be useful. Here, we report a 'Cell Dome' platform in which non-adherent cells can be enclosed and grown in the cavities of about 1 mm diameter and 270m height.

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Background: We determined the usefulness and prognostic ability of the renal risk score (RRS), proposed in Europe, for Japanese patients with antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) and high myeloperoxidase (MPO)-ANCA positivity; these aspects remain to be verified.

Methods: This retrospective study was conducted on 86 Japanese patients with new, biopsy-confirmed AAGN. We calculated the RRS and analyzed the relationship between this classification, and clinicopathological features and prognosis.

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Many plant and animal species exhibit geographic parthenogenesis, wherein unisexual (= parthenogenetic) lineages are more common in their marginal habitats such as high latitude or altitudes than their closely related bisexual counterparts. The Japanese stick insect, Phraortes elongatus (Thunberg) (Insecta: Phasmatodea), is known as a geographically parthenogenetic species due to the existence of both bisexual and unisexual populations. Here, we developed microsatellite markers to infer the genetic variation among populations of P.

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Skene's gland cysts are rare and the cause of adult-onset is still unclear. We report the case of a 34-year-old woman developing a Skene's gland cyst following a history of various gynecological treatment interventions. She finally underwent surgical excision of the cyst and no recurrence has been observed 1 year after the surgery.

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  • Luteinizing hormone-releasing hormone (LHRH) antagonists might improve lower urinary tract symptoms in prostate cancer treatment compared to agonists, but their effect on acute urinary tract toxicity during radiotherapy is unclear.
  • The study analyzed 78 patients receiving radiation therapy after 3-6 months of neoadjuvant therapy and evaluated urinary tract toxicity using a standardized grading scale.
  • Results showed no significant reduction in urinary tract toxicity with LHRH antagonists, but patients starting with moderate to severe symptoms had significantly lower scores after treatment with antagonists compared to agonists.
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Background: The prognostic significance of glomerular extracapillary hypercellularity (EXHC) in diabetic kidney disease (DKD) is unclear. The aim of this study was to investigate the clinicopathological features and outcomes of DKD patients with EXHC.

Methods: We studied 70 cases of renal biopsy-confirmed type 2 DKD that were diagnosed between 2004 and 2014 and compared the clinicopathological features and outcomes of 22 patients with EXHC (EXHC group) with those of 48 patients without EXHC (control group).

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Small cell carcinoma in the ureter is extremely rare, with few cases reported in the literature. The current report describes the case of a 63-year-old man who presented with right-side back pain. A mass was identified in the right ureter.

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The pathophysiology of bladder leiomyosarcoma, a rare disease with aggressive mesenchymal tumor, is not certain, but its main symptoms are hematuria, dysuria and abdominal pain. Cases described in the literature are few. This report describes a case of a leiomyosarcoma of the urinary bladder in a 49-year-old woman.

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Background: Three recent studies from the United States and China reported the clinicopathological features and short-term prognosis in patients with membranous nephropathy (MN) and crescents in the absence of secondary MN, anti-glomerular basement membrane (GBM) antibodies, and anti-neutrophil cytoplasmic antibodies (ANCA).

Methods: We compared clinicopathological and prognostic features in 16 MN patients with crescents (crescent group) and 38 MN patients without crescents (control group), in the absence of secondary MN, anti-GBM antibodies, and ANCA. Median follow-up periods in the crescent and control groups were 79 and 50 months, respectively.

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In order to investigate the intermediacy of 2-(4-methylpent-3-en-1-yl)anthraquinone (MPAQ), a possible intermediate for the biosynthesis of anthraquinone derivatives in sesame (Sesamum indicum), H-labeled MPAQ was administered to a hairy root culture of S. indicum. Efficient conversion of fed MPAQ to 2-[(Z)-4-methylpenta-1,3-dien-1-yl]anthraquinone ((Z)-MPDEAQ) was observed.

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Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional protein, playing roles in glucose and lipid metabolism, inflammation, angiogenesis, and tumorigenesis. Recent research suggests that ANGPTL4 is induced by hypoxia and is a useful diagnostic or prognostic marker for various cancers. However, it remains unclear whether ANGPTL4 expression influences prostate cancer.

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Calciphylaxis is rare cutaneous manifestation associated with painful skin ulceration and necrosis. It primarily occurs in patients with end-stage chronic kidney disease. In this report, we would like to show our experience with a male patient presenting with minimal change nephrotic syndrome that was sequentially complicated by acute kidney injury and painful ulcerative cutaneous lesions due to calciphylaxis.

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Mucosal immunity may play a key role in IgA nephropathy (IgAN) and IgA vasculitis with nephritis (IgAVN). IgAVN is characterized by the presence of non-thrombocytopenic palpable purpura, associated with glomerulonephritis with IgA-dominant immune deposits. Recent studies have shown the up-regulation of Toll-like receptors (TLRs) in patients with IgAN or IgAVN.

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Cerebral involvement is rare in polyarteritis nodosa(PAN);furthermore, secondary intracranial hemorrhage due to cerebral aneurysm is extremely rare. We describe an unusual case of repeated subarachnoid hemorrhage(SAH)in a 64-year-old woman with a history of PAN. Initially, she developed severe headache(probable first SAH, day 0), and presented at our hospital with second severe headache with disturbed consciousness on day 6.

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  • - A case study is presented involving a woman with a history of sarcoidosis who experienced a relapse marked by worsening kidney function, high calcium levels, kidney stones, and a ureteral stone.
  • - Her eye condition, related to sarcoidosis, was under control with topical steroids, which may have contributed to a delayed diagnosis of the disease's relapse during follow-ups.
  • - The discussion also highlights challenges in monitoring disease activity over time and deciding when treatment is necessary.
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Introduction: We previously reported cases of laparoendoscopic single-site nephrectomy performed through an umbilical or pararectal incision. To improve cosmesis and operability, we performed three Pfannenstiel laparoendoscopic reduced-port nephrectomies.

Materials And Surgical Technique: In the first case, a GelPOINT access was placed through a 2-cm umbilical incision, and two additional 3-mm trocars were inserted.

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Background: Few studies have been conducted on the long-term prognosis of patients with amyloid light chain (AL) and amyloid A (AA) renal amyloidosis in the same cohort.

Methods: We retrospectively examined 68 patients with biopsy-proven renal amyloidosis (38 AL and 30 AA). Clinicopathological findings at the diagnosis and follow-up data were evaluated in each patient.

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Tissue factor (TF), an initiator of the extrinsic blood coagulation cascade, is overexpressed in different types of cancer. Tissue factor overexpression is also known as a poor prognostic factor in pancreatic cancer. We recently developed anti-TF antibody (clone1849)-conjugated epirubicin-incorporating micelles (NC-6300), and reported that this anti-TF1849-NC-6300 showed enhanced antitumor activity against TF-high expressed human pancreatic cancer cells, when compared with NC-6300 alone.

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Tissue factor (TF) is expressed strongly in various types of cancer, especially cancers that are often refractory to treatment, such as pancreatic cancer. In this study, we compared the differences in the biophysical and pharmacological properties of whole IgG and the Fab fragment of anti-human TF monoclonal antibody (1849 antibodies), in order to determine their suitability for application in the diagnosis and treatment of cancers. In the biophysical examination, we investigated the characteristics of 1849-whole IgG and 1849-Fab by SPR sensing and confocal fluorescence microscopy analysis using recombinant human TF antigen and TF-overexpressing human pancreatic cancer cell line, BxPC3, respectively.

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  • Acute poststreptococcal glomerulonephritis (APSGN) is a disease characterized by kidney inflammation following a streptococcal infection, typically resolving on its own despite severe symptoms.
  • A case study of a 78-year-old woman revealed that after her APSGN symptoms improved, she developed primary biliary cirrhosis (PBC), suggesting that long-term immune system changes can lead to other health issues beyond the kidneys.
  • This case highlights the need for careful management of APSGN and offers insights into the connections between APSGN and the development of PBC.
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