Publications by authors named "Ryuta Kubo"
Follicular lymphoma (FL) may undergo histological transformation (HT) into a more aggressive lymphoma. Although rituximab for B-cell non-Hodgkin lymphomas (B-NHL) has greatly improved the overall survival (OS) of patients with transformed FL (tFL), relapse after anthracycline-based chemoimmunotherapy has a poor prognosis. CD19-targeting chimeric antigen receptor-modified T-cell (CAR-T) therapy is a promising treatment for relapsed or refractory (r/r) large B-cell lymphoma (LBCL), including tFL.
View Article and Find Full Text PDFEnhancing the activity of the oxygen reduction reaction (ORR) is crucial for fuel cell development, and hydrophobic species are known to increase the ORR activity. This paper reports that caffeine enhanced the specific ORR activity of Pt(111) 11-fold compared to that without caffeine in a 0.1 M HClO aqueous solution.
View Article and Find Full Text PDFLumbar spinal stenosis (LSS) is a degenerative disease characterized by intermittent claudication and numbness in the lower extremities. These symptoms are caused by the compression of nerve tissue in the lumbar spinal canal. Ligamentum flavum (LF) hypertrophy and spinal epidural lipomatosis in the spinal canal are known to contribute to stenosis of the spinal canal: however, detailed mechanisms underlying LSS are still not fully understood.
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- Hip fractures are common in people over 80, but there's limited large-scale research confirming risk factors like low bone mineral density and falls in this age group.
- A study involving 1,395 hip fracture patients and 1,075 controls used machine learning (XGBoost) to analyze 40 risk factors, achieving a high prediction accuracy.
- The research identified the top 10 key factors influencing hip fracture risk, each with specific scoring criteria, enabling better risk assessment with an optimal cutoff value of 7, which resulted in decent sensitivity and specificity.
Article Synopsis
- Radioresistance poses significant challenges in treating oral squamous cell carcinoma (OSCC), prompting researchers to create clinically relevant radioresistant (CRR) cell lines for better study of these cancers.
- The study identified FOXM1, a gene expressed in OSCC cell lines, particularly in CRR cells, and explored its role in regulating radiosensitivity and DNA damage through various experimental manipulations.
- Results indicated that targeting FOXM1, either by suppressing its expression or using inhibitors, could enhance radiosensitivity and potentially serve as a new therapeutic strategy for tackling radioresistance in OSCC.
Article Synopsis
- Researchers studied the oncolytic virus OBP-301 to see if it could effectively treat radioresistant oral squamous cell carcinoma.
- They found that OBP-301 works better when combined with radiotherapy, enhancing treatment effects and promoting cell death mechanisms like apoptosis and autophagy.
- The study showed that using OBP-301 alongside radiotherapy has significant antitumor effects in lab models, suggesting it could be a promising new treatment option for resistant cancers.