Publications by authors named "Ryusuke Ae"

Article Synopsis
  • Uric acid, produced from purine metabolism, is linked to hypertension and cardiovascular disease (CVD), with new studies emerging recently highlighting its impact.
  • Recent research indicates that hyperuricemia, caused by factors like diet and genetics, may contribute to various health issues including hypertension, kidney disease, and sleep disorders.
  • The exact causal relationship between hyperuricemia, inflammation, and oxidative stress remains uncertain, emphasizing the need for more research to understand its role in CVD and to improve treatment options.
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  • Many new nurses experience stress due to environmental changes, which can lead to resignations, highlighting the need for strategies to retain them, especially in light of Japan's nursing shortage.
  • A study analyzed the characteristics of 353 newly graduated nurses to identify factors related to early resignation, comparing traits of those who left within a year to those who stayed.
  • Results indicated that high trait anxiety and low nurse orientation are significant predictors of early resignation, suggesting that targeted support could help retain these nurses.
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  • The study aimed to identify characteristics of patients with non-refractory Kawasaki disease (KD) who responded well to standard IVIG treatment and explore factors linked to coronary artery (CA) complications.
  • A total of 69,735 non-refractory KD patients were studied, with 0.96% developing CA abnormalities, particularly influenced by initial echocardiographic findings and factors like age and gender.
  • The research concluded that about 1% of non-refractory KD patients might face CA complications and emphasized the need for timely echocardiographic assessments and early IVIG treatment initiation.
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Purpose: This study aimed to clarify whether the range of motion (ROM), anterior and posterior (AP) stability and other clinical measures changed in patients who underwent tibia-first total knee arthroplasty (TF-TKA) using navigation with a computer-aided system after surgery.

Methods: This is a retrospective study and we conducted a matched cohort analysis of 60 measured resection (MR)-TKAs and 52 TF-TKAs performed by a single surgeon. All the surgeries used the same implant and approach.

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Background: A gradually reducing radius (GRADIUS) design implant can facilitate a smooth transition from stability through full range of motion in total knee arthroplasty (TKA). Nonetheless, patient-specific factors associated with good knee flexion remain unclear.

Objective: This study aimed to determine the factors associated with good knee flexion after cruciate-retaining TKA with a GRADIUS prosthesis in an Asian population.

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A 68-year-old man was admitted with hematochezia. Emergency computed tomography showed multiple diverticula throughout the colon. Initial colonoscopy on day 2 showed no active bleeding, but massive hematochezia on day 3 led to the performance of an emergency endoscopy.

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Purpose: To assess how intraoperative macroscopical anterior cruciate ligament (ACL) findings affect perioperative procedures, biomarkers, and postoperative anterior-posterior (AP) laxity and range of motion (ROM) after cruciate-retaining (CR) total knee arthroplasty (TKA) and to determine how chronic ACL deficiency may affect postoperative inflammatory biomarker, AP laxity, and ROM.

Methods: A total of 121 patients with varus knee osteoarthritis without a history of ACL injury who underwent ATTUNE® (DePuy Synthes, Warsaw, IN) CR TKA were analyzed. Intraoperative ACL findings were stratified into intact, damaged, and diminished, according to the tension by probing, synovial coverage, and vascularity.

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Introduction During surgery, surgeons intuitively recognize when they are using dull scissors and find them difficult to use. The purpose of this study was to objectively evaluate the physical characteristics of scissors and the comfort reported by surgeons to develop objective quality control standards for scissors used in surgery. Methods Sensory and measurement tests were conducted to evaluate the comfort and physical characteristics of ten pairs of Cooper scissors.

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Article Synopsis
  • * It analyzed data from over 1.6 million hospitalized patients with acute coronary syndrome or heart failure, comparing those on XOI to those not on any urate-lowering medications.
  • * Results showed that patients on XOI had significantly lower mortality rates, while those who stopped taking XOI had much higher death rates, highlighting the need for careful management of these medications to improve patient outcomes.
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Spontaneous abdominal wall hematoma is a relatively uncommon condition triggered by various factors, including anticoagulation therapy and trauma. However, reports of unprovoked cases without anticoagulants that recur shortly after treatment are limited. We herein report an elderly woman who had been prescribed corticosteroids and experienced early recurrence of hematoma following treatment, with no discernible triggers.

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Introduction: Despite the recent increase in the use of cephalomedullary nails for trochanteric hip fractures, factors that may be associated with peri‑implant femoral fracture (PIFF) after cephalomedullary nailing for trochanteric fractures remain unknown. We investigated the factors associated with PIFF after cephalomedullary nailing of trochanteric hip fractures in older patients.

Methods: A nested case-control study was conducted using a database of patients aged ≥65 years who underwent surgery with cephalomedullary nails for trochanteric fractures caused by low-energy trauma during 2005-2021.

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Article Synopsis
  • ! Total knee arthroplasty (TKA) helps relieve pain and improve mobility for patients with severe knee osteoarthritis, but about 20% of patients experience less-than-ideal outcomes post-surgery. * ! This study investigates the intraoperative factors that influence the range of motion (ROM) after cruciate-retaining (CR) TKA, focusing on patients with knee osteoarthritis and varus knee deformity. * ! The research found that an intraoperative anterior-posterior laxity measurement of less than 10.8 mm at 30° of knee flexion is a strong indicator for achieving a knee flexion greater than 120° one year after CR-TKA, highlighting its potential as a predictive factor for better postoperative
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  • A study in Japan analyzed the epidemiological characteristics of fragility fractures of the pelvic ring (FFP), revealing an incidence rate of 35.5-121.2 per 100,000 people per year, particularly increasing after age 75.
  • Most patients (83.3%) were female, with a mean age of 82.2 years, and nearly half experienced reduced walking ability one year following their injury.
  • Significant associations were found between age, decline in walking ability, and higher mortality rates, with 1- and 5-year mortality at 15.4% and 39.9%, respectively.
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Introduction Postoperative pancreatic fistula (POPF) is a critical complication occurring with a high incidence after distal pancreatectomy. To minimize the risk of POPF, we developed an innovative pancreas ligation device capable of closing the pancreatic stump without causing traumatic injury to the pancreatic duct and artery. We conducted an follow-up study to compare the pressure resistance of the pancreas ligation device with that of a regular linear stapler.

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Purpose: To investigate whether the biomechanical properties of the healed superficial medial collateral ligament (sMCL) repaired by augmentation vary depending on the material properties of the suture augmentation.

Methods: In 8 of 10 porcines (16 hindlimbs), the sMCL was detached from the femoral attachment using a scalpel under intubated general anesthesia. sMCL repair was performed using an ultra-high-molecular-weight polyethylene (UHMWPE) tape for the right hindlimbs and polyester tape (PE) for the left hindlimbs.

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Background: AO/OTA 31A3 fractures (A3 fractures) have risk for postoperative complications with major impact on morbidity and mortality. For older patients, limited information is available for factors associated with postoperative complications. We aimed to assess factors associated with postoperative complications after surgery using cephalomedullary nails.

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Background: Distal radius fracture (DRF) is very common worldwide. In particular, aging countries have numerous patients with DRF, resulting in an urgent need for active preventive measures. As few epidemiological studies have investigated DRF in Japan, we aimed to identify the epidemiological characteristics of patients of all ages with DRF in Japan.

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Progressive multifocal leukoencephalopathy (PML) is a devastating demyelinating disease caused by JC virus (JCV), predominantly affecting patients with impaired cellular immunity. PML is a non-reportable disease with a few exceptions, making national surveillance difficult. In Japan, polymerase chain reaction (PCR) testing for JCV in the cerebrospinal fluid (CSF) is performed at the National Institute of Infectious Diseases to support PML diagnosis.

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Background: Mechanically aligned total knee arthroplasty (MATKA) is a well-established procedure. Kinematically aligned TKA (KATKA) has been proposed to restore and preserve pre-arthritic knee anatomy. However, normal knee anatomy varies widely, and there have been concerns regarding restoring unusual anatomy.

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A direct relationship between serum uric acid levels and hypertension, cardiovascular, renal and metabolic diseases has been reported in many basic and epidemiological studies. Among these, high blood pression is one of the most common features associated with hyperuricemia. In this regard, several small-scale interventional studies have demonstrated a significant reduction in blood pressure in hypertensive or prehypertensive patients on uric acid-lowering drugs.

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Article Synopsis
  • A study followed 6,576 individuals with a history of Kawasaki disease (KD) over an average of 30 years to assess long-term outcomes, particularly mortality.
  • 68 deaths were recorded, revealing that while the overall mortality rate was not higher than the general population, those with cardiac complications had a significantly increased risk of death.
  • The findings suggest that further follow-up is needed to understand the impact of KD on heart health as patients age, especially regarding atherosclerosis risk.
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Importance: Global studies have reported that the incidence of Kawasaki disease (KD) declined during the COVID-19 pandemic. These studies suggest that the global pandemic and its accompanying mitigation measures may provide an important opportunity to explore the hypothesis of a KD pathogenesis.

Objective: To compare changes in KD incidence in Japan before and after the start of the COVID-19 pandemic.

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