Reciprocal Connections between Parvalbumin-Expressing Cells and Adjacent Pyramidal Cells Are Regulated by Clustered Protocadherin γ.

Functional neural circuits in the cerebral cortex are established through specific neural connections between excitatory and various inhibitory cell types. However, the molecular mechanisms underlying synaptic partner recognition remain unclear. In this study, we examined the impact of clustered protocadherin-γ () gene deletion in parvalbumin-positive (PV) cells on intralaminar and translaminar neural circuits formed between PV and pyramidal (Pyr) cells in the primary visual cortex (V1) of male and female mice.