Publications by authors named "Ryujin Miyata"
Vasculitis is a systemic autoimmune disease characterized by leukocyte infiltration into blood vessels. Various microorganisms have been associated with the pathogenesis of vasculitis; however, the causal microbial agents and underlying mechanisms are not fully understood, possibly because of the technical limitations of pathogen detection. In the present study, we characterized the microbiome profile of patients with cutaneous vasculitis using comprehensive metagenome shotgun sequencing.
View Article and Find Full Text PDFAlthough immune checkpoint inhibitors (ICIs) are widely used to treat unresectable malignant tumors, they can cause undesirable side effects called immune-related adverse events, including neurological toxicities. Here, we describe a case of ICI-related peripheral neuropathy (irPN) with characteristic cerebrospinal fluid (CSF) findings. In addition to pleocytosis and increased protein levels, the present case showed increased levels of CSF soluble interleukin-2 receptor (sIL-2R), IL-6, and IL-10, suggesting activated T cell-related autoimmunity.
View Article and Find Full Text PDFArticle Synopsis
- * Despite evidence of infectious agents like viruses and bacteria in affected vessels, the exact connection between these infections and vasculitis remains unclear due to limitations in current research methods and animal models.
- * Advancements like metagenomic next-generation sequencing are helping researchers identify potential pathogens in tissue, highlighting the need for further studies on how microbes contribute to vasculitis in both animal models and humans.