- The study explores the function of the Gonadal soma-derived growth factor (Gsdf) gene in sex determination within the medaka fish species, Oryzias hubbsi, which has a ZW sex-determination system.
- While Gsdf shows male-dominant expression, knockout experiments indicate there’s no sex reversal and that genetic sex determination pathways remain normal without Gsdf, suggesting a different mechanism for sex differentiation in this species.
- The loss of Gsdf results in germ cell overproliferation and quicker entry into meiosis in testes but lacks the feminizing effects seen in related species, underscoring the complexity and variability of sex determination across different fish species.