Publications by authors named "Ryuichi Minato"
The Bonin Archipelago is a United Nations Educational, Scientific and Cultural Organization's World Natural Heritage Site in Japan with a unique ecosystem; however, the invasive rodents preying on endemic species have been a significant concern. The anticoagulant rodenticide, diphacinone, sprayed by the Ministry of the Environment, has succeeded; however, its repeated use leads to rodenticide resistance. This study evaluated the sensitivity by in vivo pharmacokinetics/pharmacodynamics (PK/PD) analysis and physiologically-based pharmacokinetic modeling to diphacinone in black rats (Rattus rattus) captured on the Bonin Archipelago in February 2022.
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- Anticoagulant rodenticides are used to control invasive rodents on remote islands, but they pose a risk to local wildlife, highlighting the need to assess species sensitivity to these poisons.
- The study focuses on the Bonin Islands, where diphacinone is used against black rats, and investigates the sensitivity of the native Bonin fruit bat by using Egyptian fruit bats as a model.
- Results show that while Egyptian fruit bats are sensitive to diphacinone, they excrete it slowly, indicating vulnerability, whereas they have a higher tolerance to warfarin, allowing faster recovery from its toxic effects.