Publications by authors named "Ryu Yamazaki"
Article Synopsis
- - Dysregulated yes-associated protein (YAP) is linked to various cancers, but finding effective inhibitors is challenging since YAP lacks enzymatic activity, making targeted degradation strategies promising for treatment.
- - Researchers discovered a novel compound, HK13 (derived from platanic acid), that interacts with YAP, leading to the development of hybrid compounds combining platanic acid with another drug, LCL-161, known for its affinity to E3 ubiquitin ligases.
- - Among these hybrids, HK24 was effective in inhibiting the growth of YAP overexpressing cancer cells, potentially through YAP degradation, suggesting that platanic acid could be a valuable resource in targeting YAP for cancer therapies.
