Publications by authors named "Ryu Won Kang"
Article Synopsis
- IGHV3-33 antibodies are commonly found in the immune response to the Plasmodium falciparum circumsporozoite protein, with cross-reactivity between various motifs correlating to strong parasite inhibition.
- Identification of specific residues in these antibodies reveals how they bind cross-reactively and leads to the discovery of four different binding configurations, with one linked to high effectiveness against malaria.
- The research connects the structural aspects of VH3-33 antibodies with their effectiveness, providing insights for creating antibody-based treatments against malaria.
The ubiquitin-proteasome system fulfills an essential role in regulating protein homeostasis by spatially and temporally controlling proteolysis in an ATP- and ubiquitin-dependent manner. However, the localization of proteasomes is highly variable under diverse cellular conditions. In yeast, newly synthesized proteasomes are primarily localized to the nucleus during cell proliferation.
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