Class A CpG Oligonucleotide Priming Rescues Mice from Septic Shock Activation of Platelet-Activating Factor Acetylhydrolase.

Sepsis is a life-threatening, overwhelming immune response to infection with high morbidity and mortality. Inflammatory response and blood clotting are caused by sepsis, which induces serious organ damage and death from shock. As a mechanism of pathogenesis, platelet-activating factor (PAF) induces excessive inflammatory responses and blood clotting.