Combined In Silico and Experimental Investigations of Resveratrol Encapsulation by Beta-Cyclodextrin.

The results of the computational and the physicochemical studies of the encapsulation of resveratrol with β-cyclodextrin are presented here. At first, the molecular docking experiments predicted good binding. Several MD simulations and MM-PBSA experiments confirmed the reliable binding, showing optimal kinetics and energy.

Neutrophil Oxidized-Modified Proteins and Neutrophil Extracellular Traps in Patients with Community-Acquired Pneumonia.

Materials And Methods: 51 patients with CAP were divided into 2 groups depending on the severity of the pathological process. The first group (I) consisted of 32 patients with moderate severity of pneumonia. The second group (II) consisted of 19 patients with severe pneumonia.

Obtaining and Investigation of the -Cyclodextrin Inclusion Complex with Vitamin Oil Solution.

. The research results of fat-soluble vitamin (cholecalciferol) encapsulation with -cyclodextrin have been presented in this work. The vitamin inclusion complex with -cyclodextrin was obtained under microwave radiation.

The Oxidized proteins and activity of the Cl-/HCО3- exchanger in erythrocytes of patients with acute alcohol intoxication.

Background: The purpose of this research was to study the morphological properties and the products of oxidative protein modification in erythrocytes of patients with acute alcohol intoxication. Two groups of subjects were analyzed. The first one included 39 patients with acute alcohol intoxication.

Influence of Combined Therapy on Generation of Neutrophil Extracellular Traps in Patients with Cervical Cancer.

Background: According to several authors, neutrophil extracellular traps (NETs) play an important role in the mechanisms of cancer development and metastatic processes, which allows them to be considered as a potential new target for the treatment of cancer.

Aim: To investigate the presence of extracellular neutrophil traps in the blood of patients with cervical cancer on the background of the combined treatment.

Materials And Methods: The study was conducted in 28 patients with cervical cancer.

Characteristic of the Oxidative Stress in Blood of Patients in Dependence of Community-Acquired Pneumonia Severity.

Background: At the present time the alternation of the oxidative metabolism is considered as one of the leading pathogenic mechanisms in the development and progression of community-acquired pneumonia (CAP). However the nature and direction of the oxidative protein changes in CAP patient's blood had been almost unexplored.

Aim: To define oxidative and modified proteins in erythrocytes and blood plasma of CAP patients.

Myeloperoxidase activity and the oxidized proteins in blood neutrophils of patients with pneumonia.

The main purpose of our investigation was to study myeloperoxidase activity and concentration of oxidized proteins in blood neutrophils of patients with ambulant pneumonia and secondary pneumonia which has arisen on a background of chronic obstructive pulmonary disease (COPD). Patients were divided into 2 groups. 17 patients with ambulant pneumonia moderate severity and respiratory insufficiency of grade 2 were included in the 1-st group.