The Sensitization Profile for Selected Food Allergens in Polish Children Assessed with the Use of a Precision Allergy Molecular Diagnostic Technique.

Individual populations show a variety of sensitization patterns, which may be associated with the geographic region, climate, dietary habits, or ways of preparing food. The purpose of this study was to comprehensively assess the food allergy sensitization profile in Polish children, particularly to eight food allergens (so-called "the Big 8"): cow milk, eggs, wheat, soybeans, fish, crustacean shellfish, tree nuts, and peanuts. To assess the prevalence and serum levels of specific immunoglobulins E (sIgE), we analyzed the results obtained from selected laboratories located in all regions of Poland that used the multiplex ALEX test in the period from 2019 to 2022.

Factors Influencing the Concentration of Exhaled Nitric Oxide (FeNO) in School Children Aged 8-9-Years-Old in Krakow, with High FeNO Values ≥ 20 ppb.

: Measurement of fractional exhaled nitric oxide (FeNO) concentration is currently used as a non-invasive biomarker to assess airway inflammation. Many factors can influence the FeNO level. However, there have been no reports concerning factors attributed to FeNO levels in different age groups of children, especially those with high FeNO values.

Relationship Between Air Pollution and the Concentration of Nitric Oxide in the Exhaled Air (FeNO) in 8-9-Year-Old School Children in Krakow.

The consequences of air pollution pose one of the most serious threats to human health, and especially impact children from large agglomerations. The measurement of nitric oxide concentration in exhaled air (FeNO) is a valuable biomarker in detecting and monitoring airway inflammation. However, only a few studies have assessed the relationship between FeNO and the level of air pollution.

A severity grading system of food-induced acute allergic reactions to avoid the delay of epinephrine administration.

Background: Substantial discrepancies among anaphylaxis severity scores may delay epinephrine administration.

Objective: The study aims to develop a transparent severity grading system of food-induced acute allergic reactions with a decision model for epinephrine use.

Methods: The natural course of 315 acute food-induced allergic reactions in children hospitalized at the Allergology department between May 2016 and July 2019 owing to follow-up treatment and allergy diagnostics was evaluated.

Oleosins: A Short Allergy Review.

In patients having a history of anaphylaxis after consumption of peanuts, sunflower seeds, or soy and skin or blood tests negative for the allergen extracts, oleosins could be the culprit. Oleosins are common and largely underestimated allergy inducers of plant origin, causing severe allergy symptoms, including the anaphylactic shock. They are resistant to high temperatures and digestive enzymes.

Food allergy endotype with high risk of severe anaphylaxis in children-Monosensitization to cashew 2S albumin Ana o 3.

Background: Food allergy in children can be life-threatening. Component-resolved diagnostics approach to food anaphylaxis is rarely assessed in children. The aim of the study was to identify the food allergen components as the triggers responsible for severe anaphylaxis, with regard to characteristics and associated risks, among children in a large, population-based setting.

Inhibition of Cross-Reactive Carbohydrate Determinants in Allergy Diagnostics.

Despite being clinically largely irrelevant, antibodies against cross-reactive carbohydrate determinants (CCD) are an important issue in the in vitro diagnostics, as they may produce false positive or falsely elevated results of the immunoglobulin E class (asIgE) in relation to the actually present level of asIgE. The present chapter demonstrates an effective resolution of this diagnostic issue by the use of a CCD inhibitor in in vitro tests. A synthetic CCD inhibitor, Polycheck® CCD inhibitor, was used in the laboratory diagnostics of 24 children diagnosed with allergic diseases.

[Outpatients specialist care of chronic obstructive pulmonary disease patients in Poland - results of the KOMPAS study].

Introduction: COPD is one of the most important lung diseases. It is responsible for significant proportion of outpatients pulmonary clinics visits. Data on outpatients care of COPD patients in Poland are limited.

[Bronchial challenges in asthma diagnosis].

The evaluation of bronchial hyperreactivity is useful for diagnosis atypical form asthma, in monitoring of anti-inflammatory treatment, in epidemiology and in scientific research. Different stimuli indirect and direct are applied to asses bronchial reactivity. Direct stimuli e.

[Exhaled hydrogen peroxide (H2O2) in allergic and non-allergic stable mild asthmatic children].

The evaluation of breath condensate (BC) composition is a new, non-invasive method studying inflammation processes in several respiratory diseases. Among many inflammation markers, hydrogen peroxide (H2O2) is the most common one, and its increased level was found in BC of cystic fibrosis and asthma patients. As in children's asthma, H2O2 is present and could correlates with the severity of the disease.

[The evaluation of useful breath actuated inhalers by preschool asthmatic children].

Clinical efficacy of breath actuated devices depend on value of Peak Inspiratory Flow (PIF), in consequence they are used in older children. Therefore the aim of our study was to assess the ability to use breath actuated inhalers in preschool stable asthmatic children. 156 children aged (mean and 95% CI) 4.

[Serum level of leptin and neuropeptide Y in children with mild asthma].

Leptin (LEP) and neuropeptide Y (NPY) are involved in the maintenance of energy balance and create regulatory loops on central and peripheral stage between neuropeptides and hormones, additionally regulated by other physiological stimuli. According to data confirming tendency to overweight and obesity in asthmatic children we have examined the influence of mild asthma on neurohormonal balance. 43 children, aged 7-17 years, including 27 steroid naive mild asthmatic children aged (mean+/-SD) 12.

[Diagnostic, prophylactic and therapeutic guidelines in patients with atopic dermatitis. Position paper by the task force of the National Specialists on Dermatology, Venereology and Allergology].

Treatment modalities of patients with atopic dermatitis (AD) are dependent on patient age, on the intensity of both skin symptoms and subjective signs of the disease i.e. itch and sleep disturbances, on the body surface involved with lesions, as well as on the type of sensitizing allergens.

[Effectiveness and safety of fluticasone propionate in therapy of children suffering from asthma. Part II. Safety aspects of therapy with fluticasone propionate in asthmatic children].

Inhaled administration of glucocorticoid doesn't mean lack of systemic effects of drug. Bioavailability of steroid depends on oral absorption and absorption from respiratory system. In case of fluticasone propionate (FP) swallowed dose can be neglected because almost total (>99%) inactivation in liver during first pass.

[Effectiveness and safety of fluticasone propionate in therapy of children suffering from asthma. Part I. Mechanisms of actions and clinical effectiveness of treatment in children with asthma].

The introduction of inhaled corticosteroids (ICS) has been a milestone in asthma therapy. According to current guidelines ICS are the first line drug in chronic anti-inflammatory therapy. The purpose of first part of this publication is to present updated knowledge on mechanisms of anti-inflammatory action as well as some pharmacokinetics and pharmacodynamics data about commonly used ICS, especially fluticasone propionate (FP) and two others: budesonide (BUD), beclomethasone dipropionate (BDP).

Passive smoking does not increase hydrogen peroxide (H2O2) levels in exhaled breath condensate in 9-year-old healthy children.

Environmental tobacco smoke, also called passive smoking, was shown to have adverse effects on the health of children. Hydrogen peroxide (H2O2) is proposed as a sensitive marker of oxidative injury and inflammatory processes in the airways, being increased in adult active cigarette smokers. We tested whether passive smoking had an influence on H2O2 exhalation in healthy children.

[Risk factors for atopy in schoolchildren from Cracow].

The aim of the study was to assess atopy and its risk factors in school children from Cracow. A survey of atopy in the 223 children, aged 12-14 years, in relation to developmental, environmental and social factors, was conducted in the three districts of Cracow. Atopic sensitization (SPT > 3 mm) was more prevalent in children from highly polluted district of the Stare Miasto than in children living in Prokocim and Nowa Huta (34.