Relationship between high on aspirin platelet reactivity and oxidative stress in coronary artery by-pass grafted patients.

The aim of the study was to assess the responsiveness of blood platelets to acetylsalicylic acid (ASA) in patients following coronary artery bypass grafting (CABG) surgery with relation to oxidative and antioxidative plasma status. The study included 37 patients treated with the CABG procedure. During the first 24 h after CABG patients were given 300 mg of ASA with the following dose of 150 mg daily.

Does pycnogenol intensify the efficacy of acetylsalicylic acid in the inhibition of platelet function? In vitro experience.

Introduction: Some compounds of herbal origin, such as Pycnogenol (PYC), have been considered as an aid in antiplatelet therapy. Pycnogenol, a French maritime pine bark extract, is a complex mixture of polyphenols that has the ability to reduce human smoking-induced platelet aggregation. The aim of this study was to evaluate the in vitro ability of PYC to improve the efficacy of acetylsalicylic acid (ASA) in the inhibition of platelet function.

Resistance to aspirin in patients after coronary artery bypass grafting is transient: impact on the monitoring of aspirin antiplatelet therapy.

The aim of the present study was to assess the responsiveness of blood platelets to aspirin in patients following coronary artery bypass grafting (CABG) surgery. Aspirin was administered following CABG in 24 operated patients (aged 63.2 +/- 6.

[Cold retrograde brain perfusion in repair of aortic arch dissection or aneurysm].

Unlabelled: We have used hypothermic retrograde brain perfusion (RBP) as a cerebral protection concurrently with hypothermic circulatory arrest (HCA) since September 1994. Till January 2000, 59 patients with ascending and arch aortic aneurysms were operated on (32 emergency cases with acute aortic dissection, 27 elective, including 5 with the chronic dissection). Cardio-pulmonary bypass (CPB) was established, using a common femoral artery and two venous caval cannulae, general hypothermia, aorta cross-clamping, and cold crystalloid intermittent cardioplegia via the coronary orifices.