Apolipoprotein Gene Polymorphisms (APOB, APOC111, APOE) in the Development of Coronary Heart Disease in Ethnic Groups of Kazakhstan.

Background: Previous Analysis of polymorphism of genes associated with the development of coronary heart disease (CHD) reveals that the frequency distribution of genotypes and alleles depends on the ethnic characteristics of the populations under study. Further impetus is derived from the well -established links between alcoholism (high prevalence in Kazakhstan region) and cardiovascular disorders.

Objectives: The purpose of this study was to examine a number of apolipoprotein gene polymorphisms and correlate these alleles with changes of lipid profile in CHD patients of Kazakh and Uyghur nationalities.

[Electron microscopy of Haemophilus influenzae].

The electron microscopic study of H. influenzae standard strains, serovar b, in the capsular and noncapsular forms has revealed the pronounced pleomorphism of these organisms in successive generations.

[Morphology of the oral mucosa in rats exposed to increased phosphorus levels].

The experiments on rats kept for 1, 2, 3 and 4 months in phosphorous-producing workshops revealed the influence of elementary phosphorous and its nonorganic derivatives on the mouth mucosa tissues. At the early stages of the experiments the above agents caused the increase in the number of the epithelial layer cell elements, and strengthening of the keratosis process, leading to the development of hyperkeratosis. By the end of the experiment the development of dystrophic and atrophic processes in the epithelium were observed, which sometimes caused thinning of the epithelial layer.

[Effect of large doses of vitamin A on the salivary gland secretory elements and their RNA content].

The content of RNA in secretory cells of the salivary glands was studied after administration of different doses of vitamin A. The experiments were carried out on 60 male albino mice weighing 20-25 g. The mice were given orally 1000, 3000, 5000 and 8000 IU of a 3.